A large scale evaluation of TBProfiler and Mykrobe for antibiotic resistance prediction in .

Recent years saw a growing interest in predicting antibiotic resistance from whole-genome sequencing data, with promising results obtained for and . In this work, we gathered 6,574 sequencing read datasets of public genomes with associated antibiotic resistance profiles for both first and second-line antibiotics. We performed a systematic evaluation of TBProfiler and Mykrobe, two widely recognized softwares allowing to predict resistance in .