Temporal trends in mental health terminology in Alzheimer's disease clinical trials.

Background: Despite several studies having correlated Alzheimer's disease with mental health conditions, the extent to which they have been incorporated into Alzheimer's disease clinical trials remains unclear.

Objective: This study aimed to assess the temporal trends in mental health-related terminology in Alzheimer's disease clinical trials as a proxy measure of research interest. Additionally, it sought to determine the effect of the COVID-19 pandemic on the frequency of these terms through pre-pandemic and post-pandemic trend assessment.

Granulocyte macrophage colony stimulating factor in virus-host interactions and its implication for immunotherapy.

Viruses have evolved to strategically exploit cellular signaling pathways to evade host immune defenses. GM-CSF signaling plays a pivotal role in regulating inflammation, activating myeloid cells, and enhancing the immune response to infections. Due to its central role in the immune system, viruses may target this pathway to further establish infection.

A ONECUT1 regulatory, non-coding region in pancreatic development and diabetes.

In a patient with permanent neonatal syndromic diabetes clinically similar to cases with ONECUT1 biallelic mutations, we identified a disease-causing deletion located upstream of ONECUT1. Through genetic, genomic, and functional studies, we identified a crucial regulatory region acting as an enhancer of ONECUT1 specifically during pancreatic development. This enhancer region contains a low-frequency variant showing a strong association with type 2 diabetes and other glycemic traits, thus extending the contribution of this region to common forms of diabetes.

Polarized macrophage functions are affected differentially after CSF-1R inhibition with PLX5622.

PLX5622 is a colony stimulating factor 1 receptor (CSF-1R) inhibitor that is known to deplete microglial cells in vivo. Recently its effects on macrophages (Mφ) were also observed in vivo. Therefore, we performed this study to assess its in vitro effects on the differentiation and functions of polarized Mφ derived from different tissues.

Four-year assessment of masticatory function in mandibular overdenture wearers: A randomised clinical trial comparing two to four implants to retain the prosthesis.

Background: Limited data exist on the mid- to long-term masticatory capacity of mandibular overdenture (IOD) wearers, particularly regarding the use of posterior implants to retention.

Objectives: To periodically evaluate mastication of IOD wearers, comparing the effectiveness of two to four implants to retain the prosthesis.

Methods: In a randomised controlled clinical trial, 20 complete edentulous patients (14 women), aged 51-84 years (mean age 69.

Digital Photocolorimetric Analysis of In Vitro Tooth Color Changes.

Objective: Tooth color matching is challenging, and digital photocolorimetry using eLABor_aid (eLAB) provides objective evaluation through polarized photographs. However, its comparability with spectrophotometry remains unclear.

Methods And Materials: Bovine incisor root canals (n=30) were prepared to simulate an incomplete root apex.

Digital workflow to produce 3D-printed incisal facial indirect restoration with lingual rest seats to support a removable partial denture.

A technique for fabricating lingual rest seats and indirect incisal restorations using a digital workflow is described. After intraoral scanning, the incisal edge position of the restoration and lingual rest seats for a subsequent removable partial denture (RPD) were designed digitally. Adaptation was evaluated with trial restorations, and definitive restorations were printed from a 3-dimensional resin (Varseo Smile Crown Plus Bego; Wilcos).

Clinical Tooth Color Matching: In Vivo Comparisons of Digital Photocolorimetric and Spectrophotometric Analyses.

Objective: This study aimed to compare the tooth color matching of two dental colorimetric methods: the spectrophotometric analysis (SPM) and the standardized digital photocolorimetric analysis (DPC).

Methods: The color of 60 maxillary central incisors of 30 volunteers (22.5 ± 7.

Impact of the extension of the anterior-posterior spread on quality of life and satisfaction of patients treated with implant-retained mandibular overdentures - a randomized clinical trial.

Objectives: To compare the degree of satisfaction (SD) and the impact on oral health-related quality of life (OHRQoL) of edentulous patients treated with conventional complete dentures (CCDs) and mandibular overdentures (IODs) with a short anteroposterior spread (S-APS) or a large antero-posterior spread (L-APS).

Materials And Methods: Edentulous patients were treated with CCDs and subsequently randomly allocated to receive a bar clip mandibular overdenture retained by 2 interforaminal implants (Control) or 4 (Test: 2 additional implants distal to the mental foramen). The Oral Health Impact Profile Edent questionnaire (OHIP-20E) and the Visual Analogue Scale (VAS) were applied at a mean follow-up of 38.

Diabetes mellitus lowers the chance of short-term urinary continence recovery in prostate cancer patients undergoing radical prostatectomy.

Introduction: The aim of this article was to test the impact of diabetes mellitus (DM) on short-term urinary continence in patients undergoing radical prostatectomy (RP).

Material And Methods: We relied on an institutional tertiary-care database to identify patients who underwent RP between 11/2018 and 02/2021 with data available on short-term urinary continence status (30-90 days post-surgery). Continence was defined as the usage of no or one safety-pad within 24 hours.

Molecular Spectrum in a French Cohort with Primary Dyslipidemia.

Primary hypercholesterolemia is characterized by elevated LDL-cholesterol (LDL-C) levels isolated in autosomal dominant hypercholesterolemia (ADH) or associated with elevated triglyceride levels in familial combined hyperlipidemia (FCHL). Rare variants are known in ADH and FCHL. We explored the molecular spectrum in a French ADH/FCHL cohort of 5743 unrelated probands.

Digital and Analog Analysis of Occlusion in Conventional and Implant-Retained Complete Dentures: Preliminary Results of a Prospective Clinical Trial.

Purpose: To digitally evaluate the static and dynamic occlusion of patients treated with both removable conventional complete dentures (CCDs) and implant-retained removable overdentures (IODs) and to correlate two different methods of occlusal analysis.

Materials And Methods: Eleven totally edentulous patients were treated with bimaxillary CCDs. Later, mandibular CCDs were replaced by IODs retained by either two or four implants.

Primary and Secondary Stability of Extrashort (4-mm) Implants in the Edentulous Mandible: Preliminary Results of a Prospective Clinical Trial.

Purpose: To compare the primary and secondary stability of conventional (≥ 8-mm) and extrashort (4-mm) implants in edentulous patients using different methods of assessment.

Materials And Methods: Patients underwent implant surgery and were randomly allocated into two groups: test, with two conventional implants in the anterior region and two extrashort (4-mm) implants in the posterior region; and control, with two conventional (≥ 8-mm) implants in the anterior region only. Primary stability (S1-implant placement) was assessed by insertion torque, implant stability quotient (ISQ, Osstell), and damping capacity (PTV, Periotest), while secondary stability (S2-21 days after S1; and S2-at prosthetic loading, ± 3 months after S1) was evaluated by ISQ and PTV.

Posttranscriptional Regulation of the Human LDL Receptor by the U2-Spliceosome.

Background: The LDLR (low-density lipoprotein receptor) in the liver is the major determinant of LDL-cholesterol levels in human plasma. The discovery of genes that regulate the activity of LDLR helps to identify pathomechanisms of hypercholesterolemia and novel therapeutic targets against atherosclerotic cardiovascular disease.

Methods: We performed a genome-wide RNA interference screen for genes limiting the uptake of fluorescent LDL into Huh-7 hepatocarcinoma cells.

Mutations and variants of ONECUT1 in diabetes.

Genes involved in distinct diabetes types suggest shared disease mechanisms. Here we show that One Cut Homeobox 1 (ONECUT1) mutations cause monogenic recessive syndromic diabetes in two unrelated patients, characterized by intrauterine growth retardation, pancreas hypoplasia and gallbladder agenesis/hypoplasia, and early-onset diabetes in heterozygous relatives. Heterozygous carriers of rare coding variants of ONECUT1 define a distinctive subgroup of diabetic patients with early-onset, nonautoimmune diabetes, who respond well to diabetes treatment.

Site-specific framework of sustainable practices for a Brazilian contaminated site case study.

Management of contaminated sites requires application of remediation technologies to reduce environmental and human health risks, but these actions can also produce negative effects, such as energy and natural resources consumption, greenhouse gas emissions, and impacts on local communities. The tenets of sustainability can be used to select sustainable alternatives in the environmental cleanup of these areas to reduce negative consequences and seek new solutions for site reuse. The present study evaluates seven case studies of contaminated sites to identify how sustainable practices were adopted at each site and how environmental, economic and social benefits were achieved.

Use of a stackable surgical guide to improve the accuracy of the lateral wall approach for sinus grafting in the presence of a sinus septum.

The identification and management of interfering maxillary sinus septa is essential to anticipate and prevent membrane perforation and other complications during sinus grafting. A computer-guided sinus approach based on a new magnetic stackable surgical guide was planned, to transfer the exact position of the septum and optimize the positioning of the lateral access windows. This technique reduces the risk of sinus membrane injury, thereby increasing the safety and efficacy of the procedure.

DNAJC3 deficiency induces β-cell mitochondrial apoptosis and causes syndromic young-onset diabetes.

Objective: DNAJC3, also known as P58IPK, is an Hsp40 family member that interacts with and inhibits PKR-like ER-localized eIF2α kinase (PERK). Dnajc3 deficiency in mice causes pancreatic β-cell loss and diabetes. Loss-of-function mutations in DNAJC3 cause early-onset diabetes and multisystemic neurodegeneration.

Adhesion to high-performance polymers applied in dentistry: A systematic review.

Objective: The aim of this systemic review, conducted in accordance with the PRISMA statement, was to investigate the impact of surface pretreatments on the bonding strength of high performance polymers (HPPs).

Methods: Eight databases were searched through March 2019. Risk of bias was assessed and random effects meta-analyses were applied to analyze mean differences in shear bond strength (SBS) and tensile bond strength (TBS), considering surface pretreatments and bonding agents after 24h and thermocycling.

Fixed and Removable Full-Arch Restorations Supported by Short (≤ 8-mm) Dental Implants In the Mandible: A Systematic Review and Meta-Analysis.

Purpose: To evaluate, through a systematic review of the literature, the published data regarding marginal bone loss, implant failure proportion, biologic and prosthetic complications, and risk factors associated with short (≤ 8-mm) implants supporting fixed or removable full-arch restorations in the edentulous mandible.

Materials And Methods: Two reviewers performed a search of five databases, with handsearching through the reference lists and grey literature. Controlled clinical trials and prospective cohort studies were selected in a two-phase process.

Surface treatments to improve the repair of acrylic and bis-acryl provisional materials.

Purpose: To evaluate the in vitro effects of the Composite Primer and different surface treatments on the shear bond strength (SBS) of acrylic and bis-acryl repairs with resin composite (RC).

Methods: Acrylic (Alike) and bis-acryl (Protemp 4) blocks were prepared. Surface roughness was standardized (0.

Juvenile-Onset Diabetes and Congenital Cataract: "Double-Gene" Mutations Mimicking a Syndromic Diabetes Presentation.

Monogenic forms of diabetes may account for 1-5% of all cases of diabetes, and may occur in the context of syndromic presentations. We investigated the case of a girl affected by insulin-dependent diabetes, diagnosed at 6 years old, associated with congenital cataract. Her consanguineous parents and her four other siblings did not have diabetes or cataract, suggesting a recessive syndrome.