Publications by authors named "Philippe-Antoine Bilodeau"
Article Synopsis
- Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) can lead to neurological issues like optic neuritis and transverse myelitis, with various treatment options being used for relapsing cases.
- A study reviewed the effectiveness of different treatments (steroids, B-cell depletion, IVIG, and mycophenolate mofetil) on annualized relapse rates (ARRs) and relapse-freedom in 88 patients with MOGAD.
- Results showed that IVIG had the best outcomes with the lowest ARRs and highest chance of relapse-freedom, while B-cell depletion showed the least effectiveness, particularly in pediatric patients where mycophenolate mofetil was most effective.
: This is a case of multifocal intracranial stenosis in a 74 year old male ultimately discovered to be due to Varicella Zoster Virus infection. : We highlight the importance of a broad differential diagnosis, even when the most likely etiology of intracranial stenosis is atherosclerosis. Our paper reviews the differential diagnosis as well as "red flags" for intracranial vasculopathy.
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- * In a large cohort of patients, none died, leading to an estimated upper limit of a 95% confidence interval showing a crude mortality rate of 2.1%.
- * The findings suggest that MOGAD mortality is lower than in other neuroinflammatory diseases and similar to age-adjusted mortality rates in the general U.S. population, but further research is needed to confirm these results.
: The number of immunomodulatory options approved for multiple sclerosis has increased over the past years, resulting in a better control of the disease. Depending on disease activity, neurologists can now propose treatments with different levels of efficacy, from injectable and oral treatments with modest efficacy, to highly active immunosuppressants. Nevertheless, this gain in efficacy has come with an increase in the global burden of treatment-related adverse events.
View Article and Find Full Text PDFHistorically, students have been "consumers" of undergraduate medical education (UME) rather than stakeholders in its design and implementation. Student input has been retrospective, and although UME leaders have been open to feedback, matters most important to students have often been overlooked, leaving students feeling largely unheard. Student representation has also lacked structure and unity of feedback.
View Article and Find Full Text PDFObjective: Degeneration of oligodendroglial distal processes has been identified as an early event in multiple sclerosis (MS) lesion development. Our objective was to further define the development of the "dying-back" oligodendrocyte lesion in situ and to model the development and potential reversibility of such responses using dissociated cultures of adult human brain-derived oligodendrocytes.
Methods: In situ analyses were performed on glutaraldehyde-fixed thin sections of clinically acute and pathologically active cases of MS.