Publications by authors named "Philippe Vo Van"
Objective: To assess the success rate of patent ductus arteriosus (PDA) transcatheter closure in preterm infants and to describe the nature of procedural adverse events and short-term clinical status.
Study Design: All the preterm infants with PDA transcatheter closure were evaluated retrospectively between July 2019 and March 2023 in a single level III neonatal intensive care unit in France. The procedure was performed in the catheterization laboratory using venous canulation.
Article Synopsis
- Developing brain imaging is crucial for assessing neurological health in preterm infants, as impaired brain growth is linked to negative outcomes, independent of visible brain injuries.
- This study evaluated the accuracy of cerebral ultrasound (cUS) and magnetic resonance imaging (MRI) in measuring brain structures and identifying injuries in infants born before 32 weeks of gestation at their term equivalent age (TEA).
- Results showed that cUS performed similarly to MRI for detecting hemorrhages, but MRI was better for identifying specific white matter lesions, with good inter-observer agreement on most measurements, except for some dimensions of the corpus callosum and vermis.
Article Synopsis
- This study focused on using MRI to analyze brain injuries in newborns who experienced hypoxic-ischemic events, aiming to improve understanding and prognostication in clinical settings.
- Out of 794 infants, 520 were analyzed, with 52.4% showing brain injuries predominantly in the basal ganglia, white matter, and cortex, particularly noted in those scanned before 6 days of life.
- Findings highlight that identifying specific locations and types of brain injuries can help understand their mechanisms and timing, potentially guiding future treatment and prevention strategies.
Preterm birth disrupts the in utero environment, preventing the brain from fully developing, thereby causing later cognitive and behavioral disorders. Such cerebral alteration occurs beneath an anatomical scale, and is therefore undetectable by conventional imagery. Prematurity impairs the microstructure and thus the histological process responsible for the maturation, including the myelination.
View Article and Find Full Text PDFBackground: Hypothermia is widely used for infants with hypoxic-ischemic neonatal encephalopathy but its impact remains poorly described at a population level. We aimed to describe brain imaging in infants born at ≥36 weeks' gestation, with moderate/severe encephalopathy treated with hypothermia.
Methods: Descriptive analysis of brain MRI and discharge neurological examination for infants included in the French national multicentric prospective observational cohort LyTONEPAL.
Arthrogryposis multiplex congenita is a syndromic condition defined by contracture of 2 or more joints. A large range of etiologies has been reported such as neuromuscular disorders (peripheral dysfunction), chromosomal abnormalities, or cerebral malformations (central dysfunction) leading to fetal immobility. Severity of arthrogryposis depends on the etiology and duration of fetal immobility.
View Article and Find Full Text PDFA 5-year-old girl with hereditary spherocytosis presented with two episodes of transient ischemic attacks within a month. Cranial magnetic resonance imaging angiography revealed a left internal carotid artery and middle cerebral artery stenosis, with an extensive vascular mesh in the thalamic area indicative of moyamoya disease. Treatment consisted of supporting cerebral perfusion with blood transfusions, and splenectomy to prevent recurrence.
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