Effect of statin therapy on mortality in patients with ventilator-associated pneumonia: a randomized clinical trial.

Importance: Observational studies have reported that statin use may be associated with improved outcomes of various infections. Ventilator-associated pneumonia (VAP) is the most common infection in the intensive care unit (ICU) and is associated with substantial mortality.

Objective: To determine whether statin therapy can decrease day-28 mortality in patients with VAP.