Publications by authors named "Philippe Perrottet"
Article Synopsis
- The first pentanuclear helicate was predicted based on the structures of simpler linear and tetranuclear parent compounds.
- Special organic receptors needed for this self-assembly were successfully synthesized, and the formation of these pentanuclear complexes was confirmed through NMR and ESMS spectroscopy.
- The study utilized molecular modeling to highlight the structural features of the europium pentanuclear complex, showcasing a successful combinatorial approach for creating these complex structures.
The lessons learned from p-octiphenyl beta-barrel pores are applied to the rational design of synthetic multifunctional pore 1 that is unstable but inert, two characteristics proposed to be ideal for practical applications. Nonlinear dependence on monomer concentration provided direct evidence that pore 1 is tetrameric (n = 4.0), unstable, and "invisible," i.
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- The study investigates the properties of beta-barrel ion channels featuring internal aspartates and arginine-histidine pairs through bilayer conductance experiments.
- The aspartate-containing channels exhibit cation selectivity but are unstable, with magnesium cations improving stability while diminishing selectivity.
- In contrast, arginine-histidine channels are stable, cation-selective, and exhibit unique behaviors with changes in pH and the presence of anionic molecules, highlighting the potential of these internal structures to enhance channel functionality.