Publications by authors named "Philippe Monteyne"
Article Synopsis
- Nicotine replacement therapies (NRT) aren't very effective for quitting smoking, partly due to the effects of cotinine, a metabolite of nicotine that interferes with its action.
- Research shows that cotinine acts as a weak agonist, which can reduce the effectiveness of nicotine by desensitizing receptors in the body.
- An experimental anti-cotinine vaccine was developed, leading to the production of antibodies that specifically target cotinine, which might help improve smoking cessation efforts by preventing cotinine from hindering nicotine's effects.
Early after infection, lactate dehydrogenase-elevating virus (LDV) alters the immune system by polyclonally activating B lymphocytes, which leads to IgG2a-restricted hypergammaglobulinaemia, and by suppressing the secretion of Th2 cytokines. Considering that these alterations may involve cells of the innate immune system and cytokines such as interferon-gamma (IFN-gamma), we analysed the effect of LDV on natural killer (NK) cells. Within a few days of infection, a strong and transient NK cell activation, characterized by enhanced IFN-gamma message expression and cytolysis, was observed.
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- Multiple immunotherapy approaches are being developed to treat chronic diseases, expanding from traditional uses to include conditions like cancer, autoimmunity, and even cardiovascular issues.
- Recent advancements in technology have allowed vaccines to transition from preventive measures to therapeutic options, enabling the possibility of "life-style vaccines" for managing chronic conditions in healthy individuals.
- The text will explore three specific types of vaccines—contraceptive vaccines, vaccines for treating addictions, and anti-dental caries vaccines—while discussing their technical implementation and ethical considerations.