Articular Cartilage Repair After Implantation of Hyaline Cartilage Beads Engineered From Adult Dedifferentiated Chondrocytes: Cartibeads Preclinical Efficacy Study in a Large Animal Model.

Background: Chondrocyte-based cell therapy to repair cartilage has been used for >25 years despite current limitations. This work presents a new treatment option for cartilage lesions.

Hypothesis: High-quality hyaline cartilage microtissues called Cartibeads are capable of treating focal chondral lesions once implanted in the defect, by complete fusion of Cartibeads among themselves and their integration with the surrounding native cartilage and subchondral bone.

Hyaline Cartilage Microtissues Engineered from Adult Dedifferentiated Chondrocytes: Safety and Role of WNT Signaling.

The repair of damaged articular cartilage is an unmet medical need. Chondrocyte-based cell therapy has been used to repair cartilage for over 20 years despite current limitations. Chondrocyte dedifferentiation upon expansion in monolayer is well known and is the main obstacle to their use as cell source for cartilage repair.

Conventional Radiographs and Magnetic Resonance Imaging for the Analysis of Trochlear Dysplasia: The Influence of Selected Levels on Magnetic Resonance Imaging.

Background: Trochlear dysplasia is one of the most important risk factors for recurrent patellar instability. It is defined on true lateral conventional radiographs (CR) and axial magnetic resonance imaging (MRI). The type of trochlear dysplasia is decisive for surgical treatment; however, low agreement between CR and MRI has been reported.

Abuse of medication during international football competition in 2010 - lesson not learned.

Background: The use of medication in professional football has previously been shown to defy clinical guidelines.

Materials And Methods: Physicians of the teams who participated at the 2010 FIFA World Cup provided the list of medications used by each player within the 72 h preceding every match.

Results: During the tournament 71.