Publications by authors named "Philippe Lehours"

Article Synopsis
  • - This study reports the first isolation of a newly identified bacteria species from two patients in France suffering from gastroenteritis, using samples collected in 2020 and 2022.
  • - Both isolates were confirmed to belong to the same species through various methods including biochemical tests, electron microscopy, and genetic analyses, and they exhibited significant cytopathogenic activity in human intestinal cells.
  • - The findings highlight the importance of utilizing next-generation sequencing for accurate species identification. It underscores the need to recognize emerging pathogens like this new species as potential foodborne threats to public health.
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  • Campylobacteriosis is the leading bacterial cause of diarrhea in kidney transplant recipients (KTRs), but risk factors for this infection remain unclear.
  • A 10-year study in France identified 326 KTRs with campylobacteriosis, revealing an incidence rate of 2.3 cases per 1,000 patient-years, primarily occurring around 2.4 years after transplantation.
  • The main risk factors for developing campylobacteriosis include the use of corticosteroids, acute rejection episodes, low lymphocyte counts, and low estimated glomerular filtration rate (eGFR); treatment should prioritize azithromycin due to high resistance to fluoroquinolones.
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  • - Coagulase-negative staphylococci (CONS) are a leading cause of late-onset sepsis in preterm infants, and this study investigates the effectiveness of continuous versus intermittent vancomycin infusion in treating these infections.
  • - The study looked at 110 neonates, showing that those on continuous infusion had significantly lower treatment failure rates (17% vs. 44%) and achieved therapeutic drug levels more frequently than those on intermittent infusion.
  • - The findings suggest that using adjusted continuous vancomycin infusion might be safer and more effective for treating CONS bacteremia in neonates, but further research is necessary to confirm these results due to the study's observational nature.
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Background: Helicobacter pylori infection-associated gastric adenocarcinoma is influenced by various factors, including the digestive microbiota. Lactic acid bacteria role in digestive carcinogenesis has been discussed, and some Lactobacillaceae family species have been shown to act against H. pylori-induced inflammation and colonization.

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Gastric cancer's (GC) bad prognosis is usually associated with metastatic spread. Invasive cancer stem cells (CSC) are considered to be the seed of GC metastasis and not all CSCs are able to initiate metastasis. Targeting these aggressive metastasis-initiating CSC (MIC) is thus vital.

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Resistance in to tetracycline is rare. We describe the case of an strain with a high level of resistance to tetracycline (minimum inhibitory concentration = 12 mg/L). However, despite tetracycline resistance, bismuth quadritherapy was effective.

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Introduction: Aminopenicillins resistance among and strains is associated with a single mutation in the promoting region of a chromosomal beta-lactamase , allowing its expression. Clavulanic acid is used to restore aminopenicillins activity in case of expression and has also an inherent antimicrobial activity over spp. Resistance to amoxicillin-clavulanic acid is therefore extremely rare among these species: only 0.

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Background: Gastric Mucosa Associated Lymphoid Tissue lymphoma (GML) development is triggered by Helicobacter pylori (H. pylori) infection. Little is known about the impact of H.

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In June 2021, a cluster of seven cases of infections occurred in a rehabilitation center and caused significant morbidity in elderly patients including five with bacteremia and two with osteoarticular medical device infections. The genetic identity identified by whole genome sequencing of the different strains confirms a common source. This foodborne illness outbreak may have resulted from the consumption of unpasteurized dairy products, such as a cow's raw milk cheese resulting from a farm-to-fork strategy.

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We present two independent cases of recurrent multidrug-resistant Campylobacter jejuni infection in immunocompromised hosts and the clinical challenges encountered due to the development of high-level carbapenem resistance. The mechanisms associated with this unusual resistance for were characterized. Initial macrolide and carbapenem-susceptible strains acquired resistance to erythromycin (MIC > 256mg/L), ertapenem (MIC > 32mg/L), and meropenem (MIC > 32mg/L) during treatment.

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Objectives: The study aimed to describe the dynamics and risk factors of Gram-negative bacteria (GNB) acquisition in preterm infants.

Methods: This prospective multicenter French study included mothers hospitalized for preterm delivery and their newborns, followed until hospital discharge. Maternal feces and vaginal fluids at delivery, and neonatal feces from birth to discharge were tested for cultivable GNB, potential acquired resistance, and integrons.

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PCR detection of Helicobacter pylori infection in gastric biopsies allows the detection of this bacterium and the mutations associated with macrolide resistance. The aim of this study was to evaluate the performance of RIDA®GENE H. pylori PCR (r-Biopharm) on the ELITe InGenius System (Elitech).

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Helicobacter cinaedi bacteremia caused recurring multifocal cellulitis in a patient in France who had chronic lymphocytic leukemia treated with ibrutinib. Diagnosis required extended blood culture incubation and sequencing of the entire 16S ribosomal RNA gene from single bacterial colonies. Clinicians should consider H.

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The incidence of campylobacteriosis has substantially increased over the past decade, notably in France. Secondary localizations complicating invasive infections are poorly described. We aimed to describe vascular infection or endocarditis caused by Campylobacter spp.

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Eosinophils may reside in the lower intestine to play several homeostatic functions. Regulation of IgA+ plasma-cell (PC) homeostasis is one of these functions. Here, we assessed regulation of expression for a proliferation-inducing ligand (APRIL), a key factor from the TNF superfamily for PC homeostasis, in eosinophils from the lower intestine.

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Background: Cancer stem cells (CSCs) are at the origin of tumour initiation and progression in gastric adenocarcinoma (GC). However, markers of metastasis-initiating cells remain unidentified in GC. In this study, we characterized CD44 variants expressed in GC and evaluated the tumorigenic and metastatic properties of CD44v3+ cells and their clinical significance in GC patients.

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Article Synopsis
  • * A study of 67 patients over 19 years in France identified the main infectious strains as V. alginolyticus, V. parahaemolyticus, and others, with significant drug resistance observed.
  • * 36% of patients experienced severe outcomes like septic shock or death, highlighting the need for doctors to consider vibriosis in at-risk patients.
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Members of the Campylobacter lari group are causative agents of human gastroenteritis and are frequently found in shellfish, marine waters, shorebirds, and marine mammals. Within a One Health context, we used comparative genomics to characterize isolates from a diverse range of sources and geographical locations within Europe and Australia and assess possible transmission of food, animal, and environmental isolates to the human host. A total of 158 C.

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  • - Neonatal toxic shock syndrome-like exanthematous disease (NTED) is a rare illness caused by superantigenic toxins from Staphylococcus aureus, first identified in Japan in the 1990s.
  • - Diagnosis involves observing generalized skin redness (macular erythema) along with fever, low platelet count (thrombocytopenia), and mild C reactive protein levels without other explanations.
  • - The report discusses four cases from France involving both methicillin-sensitive and methicillin-resistant Staphylococcus aureus, highlighting the need for better awareness and management of this underrecognized condition among medical professionals.
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Background: Gastric cancer, the fifth most common cancer worldwide, is mainly linked to infection. induces chronic inflammation of the gastric mucosa associated with high oxidative stress. Our study aimed at assessing the implication of Nrf2, a major regulator of cellular redox homeostasis, in -induced gastric carcinogenesis.

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Aliarcobacter butzleri is an emerging gastrointestinal pathogen found in many countries worldwide. In France, it has become the third most commonly isolated bacterial species from the stools of patients with intestinal infections. No interpretative criteria for antimicrobial susceptibility testing have been proposed for A.

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PCR detection of Helicobacter pylori infection in gastric biopsies allows the detection of this bacterium and the mutations associated with macrolide resistance. The aim of this study was to evaluate the performance of RIDA®GENE H. pylori PCR (r-Biopharm) on a BD MAX™ System (Becton Dickinson).

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