Publications by authors named "Philippe Ladure"
Milnacipran, a serotonin and noradrenalin reuptake inhibitor (SNRI), is efficacious in rodents in various models of acute or chronic pain (traumatic, neuropathic, inflammatory, visceral). However, its activity against arthritic pain has never been explored. Here, we assessed the activity of acute treatment with milnacipran in a polyarthritic rat model.
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- - Milnacipran, an SNRI, has demonstrated effectiveness in treating chronic pain conditions, particularly fibromyalgia, and shows promise in alleviating neuropathic pain in rats using a chronic constriction injury model.
- - In experiments, milnacipran significantly reduced both thermal and mechanical allodynia with effective doses identified for acute (2.5mg/kg for cold, 10mg/kg for mechanical) and sub-chronic (10mg/kg) treatments.
- - Comparatively, amitriptyline, a tricyclic antidepressant, was effective mainly against mechanical allodynia and less effective for thermal pain, indicating milnacipran's superior performance against nerve-related pain types.