Publications by authors named "Philippe J-L Y Gevenois"
Article Synopsis
- IL-13 is a cytokine primarily produced by Th2 cells, involved in allergic responses, inflammation, and fibrosis, making it a target for therapeutic research, though human clinical trials with conventional antibodies targeting IL-13 have mainly been unsuccessful.
- Nanobodies, derived from camel antibodies, show promise due to their small size and ability to be engineered for targeted therapies, particularly in local administration.
- This study successfully developed 38 nanobodies, with some showing good affinity, and through creating multimeric constructs, researchers significantly improved their effectiveness against IL-13 while maintaining specificity.
