Publications by authors named "Philippe Flahaut"
Clinical course and cost assessment of infants with a first episode of acute bronchiolitis presenting to the emergency department: Data from the GUERANDE clinical trial.
Pediatr Pulmonol
December 2021
Introduction: Bronchiolitis is the leading cause of hospitalization for infants but its economic burden is not well documented. Our objective was to describe the clinical evolution and to assess the 1-month cost of a first episode of acute bronchiolitis presenting to the emergency department (ED).
Methods: Our study was an epidemiologic analysis and a cost study of the cohort drawn from the clinical trial GUERANDE, conducted in 24 French pediatric EDs.
Background: Since several malaria parasite species are usually present in a particular area, co-infections with more than one species of Plasmodium are more likely to occur in humans infected in these areas. In many mixed infections, parasite densities of the cryptic species may be low and often not recognized in clinical practice.
Case Presentation: Two children (3 and 6 years old) adopted recently from Central African Republic were admitted to hospital because of intermittent fever.
Article Synopsis
- Acute bronchiolitis is a major reason for hospitalizations in infants, and previous research suggested limited effectiveness of nebulized hypertonic saline (HS) treatment in emergency settings.
- The GUERANDE study was a large, multicenter clinical trial that aimed to determine if nebulized HS could reduce hospital admissions for infants experiencing their first acute bronchiolitis episode.
- Results showed no significant difference in hospital admission rates between the HS group (48.1% admitted) and the normal saline (NS) group (52.2% admitted), although the HS group did show greater improvement in respiratory distress symptom scores.
We describe the case of a young patient with calcifying encephalopathy, born to asymptomatic parents. An extensive hypothesis-driven etiological assessment was performed and failed to detect the precise etiology during many years. We therefore decided to perform whole exome sequencing of the child-unaffected parents trio.
View Article and Find Full Text PDFAcrodysostosis is a rare autosomal-dominant condition characterized by facial dysostosis, severe brachydactyly with cone-shaped epiphyses, and short stature. Moderate intellectual disability and resistance to multiple hormones might also be present. Recently, a recurrent mutation (c.
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