Publications by authors named "Philippe Donnen"

Background: In South Kivu (Eastern Democratic Republic of the Congo [DRC]), health districts (HDs) affected by chronic armed conflicts are devising coping mechanisms to continue offering healthcare services to the population. Nonetheless, this alone does not suffice to make them fully resilient to such conflicts. This study aims to explore the characteristics of these HDs' resilience.

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Background: Little is known about the use of mid-upper arm circumference for age (MUACZ) for diagnosing of severe acute malnutrition (SAM) and its correlation with WHZ (weight-for-height Z-score) in an area endemic for severe acute malnutrition (SAM) and with a high prevalence of kwashiorkor. Our study aims to analyze the concordance between the diagnostic criteria of SAM in a region presenting these characteristics.

Methods: We analyzed a database of children admitted from 1987 to 2008 for the management of SAM in Eastern Democratic Republic of Congo.

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Article Synopsis
  • * The study, conducted from August 2019 to March 2020, involved 594 pregnant women, revealing a 54.4% anemia prevalence, with moderate and severe cases at 49.2% and 5.2%, respectively.
  • * Key factors contributing to anemia included being under 20 years old and having malaria; the research suggests that enhancing malaria prevention efforts is crucial for young pregnant women to combat maternal anemia.
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Background: Despite growing evidence on the short-term deleterious effects of severe acute malnutrition (SAM) in childhood on hematopoiesis, little is known about the long-term hematological effects of SAM in low-income countries (LICs). Our study explored the association between childhood SAM and hematological disorders in adults 11 to 30 years after post-SAM nutritional rehabilitation.

Methods: This follow up study investigated 97 adults (mean age 32 years) treated for SAM during childhood in eastern Democratic Republic of the Congo (DRC) between 1988 and 2007.

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Objective: Overweight and obesity constitute a new challenge in low-income and middle-countries. The obesity prevention programme, called '5-2-1-0', promotes healthy eating habits, physical activity and limited screen time among young people.This study aimed to assess adherence to the '5-2-1-0' recommendations and to study multiple risky behaviours among adolescents in nine countries in sub-Saharan Africa.

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Background: Few studies have assessed the relationship between weight-for-height (WHZ) and mid-upper arm circumference (MUAC) with hospital mortality considering confounders. The particularity of MUAC for age (MUACZ) is less documented.

Objective: This study aims to investigate this relationship in a region endemic for severe acute malnutrition (SAM).

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Background: Exposure during pregnancy to malaria and sexually-transmitted infections is associated with adverse birth outcomes including low birth weight (LBW). This study aimed at assessing if the adjunction of two doses of azithromycin to sulfadoxine-pyrimethamine for the intermittent preventive treatment of malaria in pregnancy can reduce LBW.

Methods: A two parallel-groups, open-label randomized controlled trial involving pregnant women (16 to 35 years of age and 12 to 24 weeks of gestation as confirmed by last menstrual period or fundal height) was conducted in rural Burkina Faso.

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Background: The Eastern part of the Democratic Republic of Congo (DRC) has been affected by armed conflict for several years. Despite the growing interest in the impact of these conflicts on health service utilisation, few studies have addressed the coping mechanisms of the health system. The purpose of this study is to describe the traumatic events and coping mechanisms used by the health zones (HZs) in conflict settings to maintain good performance.

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Background: Anemia during pregnancy has been linked to higher maternal and perinatal morbidity and mortality. The purpose of this study is to examine the impact of individualized home-based care for pregnant women on pregnancy outcomes.

Methods: This was a cluster-randomized experiment done in Burkina Faso's Sindou health area between 2015 and 2016.

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Article Synopsis
  • The WHO emphasizes the need for continuous malaria surveillance in endemic regions to focus targeted interventions on at-risk populations.
  • A study in rural Burkina Faso involving 1,067 first antenatal care attendees found a 16.1% prevalence of malaria, with significant associations linked to factors like age under 20, anemia, lack of bed net use, and absence of preventive treatment.
  • The findings indicate a critical need to enhance malaria prevention strategies during early antenatal care visits to reduce negative health effects for pregnant women and their babies.
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Background: Long-term impact of different forms of severe acute malnutrition (SAM) in childhood on the emergence of noncommunicable diseases (NCDs) is poorly known. Aim: To explore the association between subtypes of SAM during childhood, NCDs, and cardiovascular risk factors (CVRFs) in young adults 11 to 30 years after post-SAM nutritional rehabilitation. Methods: In this follow-up study, we investigated 524 adults (mean age 22 years) treated for SAM during childhood in eastern Democratic Republic of the Congo (DRC) between 1988 and 2007.

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Background: Malnutrition is a public health problem, but outside the theoretical framework, little is known about the concrete intergenerational effects of malnutrition.

Objective: The objective of this study is to compare the nutritional status and health indicators of school children born to mothers who were treated for severe acute malnutrition (SAM).

Methodology: The study took place in Miti-Murhesa health zone in the Democratic Republic of Congo.

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Article Synopsis
  • Low birth weight (LBW) is a significant cause of neonatal mortality in developing countries, with rising concern in sub-Saharan Africa due to limited data for effective intervention.
  • A study in Yako, Burkina Faso, involved a survey of 600 mothers and their newborns, finding an 11% prevalence of LBW and identifying key risk factors such as maternal malaria, low preventive treatment uptake, and being a primigravid mother.
  • Results indicate that despite mothers’ antenatal visits, these factors contribute to LBW, highlighting the need for improved maternal health strategies in rural areas.
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Introduction: Stroke is a major public health concern. It is a frequent pathology, 80% of which is of ischemic origin. Approximately 86% of all stroke deaths worldwide occur in low- and middle-income countries.

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Background: Malaria and sexually transmitted/reproductive tract infections (STI/RTI) are leading and preventable causes of low birthweight in sub-Saharan Africa. Reducing their impact on pregnancy outcomes requires efficient interventions that can be easily integrated into the antenatal care package. The paucity of data on malaria and STI/RTI coinfection, however, limits efforts to control these infections.

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Article Synopsis
  • This study focuses on estimating the prevalence of low birthweight (LBW) in the rural area of Nanoro, Burkina Faso, where limited data previously existed.* -
  • Of the 291 newborns examined, 12% were found to have LBW, with significant associations linked to factors like being a first-time mother, having a history of stillbirth, and not using insecticide-treated bed nets during pregnancy.* -
  • The findings highlight a pressing public health issue in Burkina Faso and suggest a need to improve antenatal care services to better address risks associated with low birthweight.*
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Background: Malnutrition is a public health problem, as wasting affects 7.5% of children worldwide. The harmful effects of severe acute malnutrition (SAM) can last a lifetime, but how SAM in childhood affects later breastfeeding ability is not clear.

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Article Synopsis
  • - The study investigates body composition in young adults who experienced severe acute malnutrition (SAM) in childhood and compares them to unexposed peers in the Democratic Republic of the Congo.
  • - Out of 151 SAM-exposed adults studied, males had significantly lower weight and height, and a decrease in fat-free mass (FFM), particularly pronounced in males compared to females.
  • - Overall, while SAM was linked to reduced FFM in adulthood, adjusting for height showed no differences in fat mass or height-normalized body composition between the two groups.
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Introduction: anaemia in pregnancy is a public health concern in Burkina Faso. This study aims at identifying the factors associated with the prevalence of anaemia in pregnant women at a regional level in Burkina Faso.

Methods: we conducted a cross-sectional study in the region called "Cascades", located at the Western part of Burkina Faso.

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Burkina Faso has high prevalence of anemia in pregnancy (hemoglobin < 11 g/dL), despite the implementation of the WHO recommended guidelines. This study aimed to test the effects of personalized support for pregnant women at home on the trend of anemia prevalence in pregnancy. A cluster randomized trial was conducted from January 2015 to August 2016 at Sindou health district in Burkina Faso.

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Background: In 2016, a free healthcare policy (FHP) was implemented in Burkina Faso for children under the age of five. In our study, we aimed to determine the prevalence of care-seeking for a fever in children under the age of five before and after the implementation of the FHP and to analyze the determinants of not seeking care under the FHP.

Methods: The data of three nationally representative surveys were used to evaluate the trends of the prevalence of care-seeking.

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Introduction: Little is known about the long-term outcomes of Severe Acute Malnutrition (SAM) during childhood. As such, this study aims to explore the association between childhood SAM and blood pressure (BP) in adulthood in a context without nutrition transition.

Methodology: We identified 524 adults (Median age: 22 years) who were treated for SAM during childhood in Eastern DRC between 1988 and 2007.

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Article Synopsis
  • The study examined the long-term impact of severe acute malnutrition (SAM) in childhood on adult health and socioeconomic status in a specific population in the Democratic Republic of Congo.
  • 524 adults previously treated for SAM were compared to 407 individuals without a SAM history, revealing that those affected by SAM showed increased cardiometabolic risks and a higher likelihood of metabolic syndrome.
  • The results suggest that childhood SAM is linked to an elevated risk of noncommunicable diseases (NCDs) and poorer human capital in adulthood, highlighting the need for attention from policymakers to address these issues.
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This cross-sectional study was conducted to determine the association between selected characteristics and body composition of mothers and children in early life. This study included 213 mother-child pairs 6 to 8 months involving in the cohort study of the Research and Development Project conducted in Kaffrine district. The main outcomes were fat-free mass (FFM) and body fat (BF), measured using deuterium dilution method and anthropometry.

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Introduction: Little is known about the outcomes of subjects with a history of severe acute malnutrition (SAM). We therefore sought to explore the long-term effects of SAM during childhood on human capital in adulthood in terms of education, cognition, self-esteem and health-related disabilities in daily living.

Methodology: We traced 524 adults (median age of 22) in the eastern Democratic Republic of the Congo, who were treated for SAM during childhood at Lwiro hospital between 1988 and 2007 (median age 41 months).

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