Publications by authors named "Philippe Brissaud"
Objective: To identify biomarkers of articular and ocular disease activity in patients with Blau syndrome (BS).
Methods: Multiplex plasma protein arrays were performed in five BS patients and eight normal healthy volunteers (NHVs). Plasma S100A12 and S100A8/9 were subsequently measured by ELISA at baseline and 1-year follow-up in all patients from a prospective multicentre cohort study.
Article Synopsis
- The study aims to provide initial and follow-up findings from a 5-year examination of Blau syndrome, focusing on eye disease in patients.
- Data were collected from 50 patients across 25 global centers, revealing that a significant majority experienced uveitis and many had moderate to severe visual impairment.
- The findings indicate that Blau uveitis leads to progressive eye complications despite treatments, emphasizing the necessity for ongoing eye monitoring and the need for improved therapeutic options.
Objective: To report baseline articular, functional and ocular findings of the first international prospective cohort study of Blau syndrome (BS).
Methods: Three-year, multicentre, observational study on articular, functional (HAQ, Childhood HAQ and VAS global and pain), ophthalmological, therapeutic and radiological data in BS patients.
Results: Baseline data on the first 31 recruited patients (12 females and 19 males) from 18 centres in 11 countries are presented.
Synovial metastases from neoplasms are uncommon. We report two cases of knee monoarthritis due to joint metastasis. Joint fluid cytology established the diagnosis.
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