Publications by authors named "Philippa Graham"
Article Synopsis
- MIV-711 is a selective cathepsin K inhibitor that showed potential benefits for bone and cartilage in osteoarthritis models, and this study aimed to assess its efficacy and safety in knee osteoarthritis patients.
- The 26-week trial involved 244 participants, who were randomly assigned to receive either MIV-711 at 100 mg or 200 mg doses or a placebo, with the primary outcome focused on pain reduction measured by a numerical rating scale (NRS).
- While MIV-711 did not significantly reduce pain scores compared to placebo, it did show a significant decrease in bone area progression and cartilage thinning, with few serious adverse events noted that weren't deemed treatment-related.
Context: This paper considers the advantages of shadowing foundation-year doctors (FY1) in the third year of medical school, an opportunity the UK's General Medical Council (UKGMC) recommends to be given to final-year students only.
Method: Eighteen students spent 1 day each shadowing an FY1, holding their pager and carrying out their duties under direct supervision. Questionnaires, based on UKGMC expectations of an FY1, were completed assessing students' confidence and experience before and after the shifts.