Publications by authors named "Philipp Vermehren"
Article Synopsis
- Atrial fibrillation (AF) is a major cause of ischemic stroke in the elderly, with a study revealing that 28% of hospitalized stroke patients had AF-associated strokes, especially in North America and Europe.
- Most cases involved patients already diagnosed with AF or newly found AF through electrocardiograms, while only 2% were detected unexpectedly through post-stroke monitoring.
- The study found that patients with AF-associated strokes were generally older (average age of 75) and had higher 30-day mortality rates compared to those without AF, highlighting the need for effective detection methods tailored to older populations.
Background: Recent evidence supports that most non-lacunar cryptogenic strokes are embolic. Accordingly, these strokes have been designated as embolic strokes of undetermined source (ESUS).
Aims: We undertook an international survey to characterize the frequency and clinical features of ESUS patients across global regions.
The dichotomy of memantine treatment for ischemic stroke: dose-dependent protective and detrimental effects.
J Cereb Blood Flow Metab
February 2015
Excitotoxicity is a major contributor to cell death during the acute phase of ischemic stroke but aggressive pharmacological targeting of excitotoxicity has failed clinically. Here we investigated whether pretreatment with low doses of memantine, within the range currently used and well tolerated for the treatment of Alzheimer's disease, produce a protective effect in stroke. A coculture preparation exposed to modeled ischemia showed cell death associated with rapid glutamate rises and cytotoxic Ca(2+) influx.
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