Publications by authors named "Philipp Stoffers"

Article Synopsis
  • The study emphasizes the importance of accurately assessing risks in patients with Acute-on-Chronic Liver Failure (ACLF), as it is linked to high short-term mortality, particularly for liver transplant decisions.
  • The research found that patients with pulmonary impairment face significantly higher mortality rates, with those experiencing pulmonary failure having an alarming 83.7% mortality within 28 days.
  • Adjusting the CLIF-C ACLF score to account for the level of pulmonary impairment can improve the prediction of outcomes, suggesting that both pulmonary failure and mechanical ventilation are critical factors for evaluating the prognosis of ACLF patients.
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Background: The transition from compensated to decompensated liver cirrhosis is a hallmark of disease progression, however, reliable predictors to assess the risk of decompensation in individual patients from routine diagnostics are lacking. Here, we characterize serum levels of cell death-associated markers and routine biochemistry from patients with chronic liver disease with and without decompensation.

Methods: A post-hoc analysis was based on prospectively collected clinical data from 160 patients with chronic liver disease, stably compensated or decompensated at baseline or during follow-up, over a median period of 721 days.

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Background: Before performing endoscopy to remove prophylactic pancreatic stents placed in patients with high risk of post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP), X-ray imaging is recommended to confirm the stents position in the pancreatic duct.

Objectives: The aim of the present study was to investigate the feasibility of prophylactic pancreatic stent detection by transabdominal ultrasonography, to reduce the burden of X-ray imaging, which is currently the golden standard.

Methods: All patients who received a pancreatic stent for PEP prophylaxis were included in the present prospective trial.

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Background: Chronic hepatitis C virus (HCV) infections are causally linked with metabolic comorbidities such as insulin resistance, hepatic steatosis, and dyslipidemia. However, the clinical impact of HCV eradication achieved by direct-acting antivirals (DAAs) on glucose and lipid homeostasis is still controversial. The study aimed to prospectively investigate whether antiviral therapy of HCV with DAAs alters glucose and lipid parameters.

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