Publications by authors named "Philipp Schnatzer"
Introduction: CD4⁺CD25⁺/highCD127low/⁻ regulatory T cells (Tregs) play a crucial role in maintaining peripheral tolerance. Data about the frequency of Tregs in rheumatoid arthritis (RA) are contradictory and based on the analysis of peripheral blood (PB) and synovial fluid (SF). Because Tregs exert their anti-inflammatory activity in a contact-dependent manner, the analysis of synovial membrane (SM) is crucial.
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- Cartilage degeneration in osteoarthritis (OA) alters chondrocyte metabolism, prompting research into gene expression and microRNA (miR) levels in affected and normal knee cartilage.
- Key candidate molecules associated with OA include H19, IGF2, and ITM2A, with H19 being a long noncoding RNA potentially linked to important regulatory functions.
- The study reveals H19's expression is influenced by hypoxic conditions and inflammation; it may serve as a marker for cartilage health and a target for therapeutic strategies to encourage cartilage repair.
Background: Musculoskeletal pain represents a continuous process ranging from single-site to multiple-site pain, with an increase in pain sites accompanied by an increasing risk of chronification and the development of further comorbidities. Within this context, the impact of pain spread on therapy outcome is still unknown.
Aims: This prospective clinical study aimed to evaluate whether and to what extent patients with pain at multiple sites would also benefit from multidisciplinary therapy or whether therapy success is limited by pain spread.