Single crystal growth of water-soluble metal complexes with the help of the nano-crystallization method.

The Nano-Crystallization method has been extensively tested for the growth of single crystals of cationic coordination compounds, which are soluble in water. All three studied, diverse metal complexes could be crystallized with the help of pipetting robots commonly used for the crystallization of proteins and the anion small molecule screen. It was furthermore possible to obtain for each positively charged complex several structures with different anions.

Microbatch under-oil salt screening of organic cations: single-crystal growth of active pharmaceutical ingredients.

Multicomponent solid forms of active pharmaceutical ingredients represent a modern method of tuning their physicochemical properties. Typically, salts are the most commonly used multicomponent solid form in the pharmaceutical industry. More than 38% are formulated as organic cations.

A high throughput screening method for the nano-crystallization of salts of organic cations.

The generation of solid salts of organic molecules is important to the chemical and pharmaceutical industry. Commonly used salt screening methods consume a lot of resources. We employed a combination of ion exchange screening and vapour diffusion for crystallization.