Publications by authors named "Philipp Niggemann"
Article Synopsis
- Genome editing has revolutionized the creation of personalized therapies, potentially allowing treatment for up to 90% of human genetic mutations.
- Hearing loss is a key area of study, with over a hundred genes linked to deafness, and innovative delivery methods for gene therapy have been tested in animal models.
- Recent research shows promising results for genome and base editing in the inner ear, with ongoing preclinical development addressing future challenges in treating both genetic and non-genetic hearing loss.
Different glomerular diseases that affect podocyte homeostasis can clinically present as nephrotic syndrome with massive proteinuria, hypoalbuminemia, hyperlipidemia and edema. Up to now, no drugs that specifically target the actin cytoskeleton of podocytes are on the market and model systems for library screenings to develop anti-proteinuric drugs are of high interest. We developed a standardized proteinuria model in zebrafish using puromycin aminonucleoside (PAN) via treatment in the fish water to allow for further drug testing to develop anti-proteinuric drugs for the treatment of glomerular diseases.
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