Publications by authors named "Philipp N Braaker"
Article Synopsis
- The text discusses the increasing importance of optical recording for studying molecular dynamics in biology, aided by advancements in biosensors and microscopy.* -
- It introduces AQuA2, a new data analysis platform powered by machine learning, designed to accurately and efficiently analyze complex data from live imaging.* -
- AQuA2 enables the identification of molecular activities and functional units, with applications demonstrated in various biological contexts, such as studying neuron and astroglia interactions and signal patterns in mouse spinal cords.*
In non-mammalian vertebrates, some neurons can regenerate after spinal cord injury. One of these, the giant Mauthner (M-) neuron shows a uniquely direct link to a robust survival-critical escape behavior but appears to regenerate poorly. Here we use two-photon microscopy in parallel with behavioral assays in zebrafish to show that the M-axon can regenerate very rapidly and that the recovery of functionality lags by just days.
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