Publications by authors named "Philipp Lotz"
The intestinal bile acid carrier ASBT (), the hepatic bile acid carrier NTCP (), and the steroid sulfate carrier SOAT (), all members of the solute carrier family SLC10, are established drug targets. The ASBT inhibitors odevixibat, maralixibat, and elobixibat are used to treat intrahepatic cholestasis, cholestatic pruritus, and obstipation. The peptide drug bulevirtide blocks binding of the hepatitis B and D viruses to NTCP and thereby inhibits the virus's entry into hepatocytes.
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- The study focuses on identifying lemon and lime juice adulterations through specific chemical markers, such as coumarins and psoralens.
- Challenges were noted due to manufacturing practices that could lead to misleading results, prompting the need for a detailed analysis of juice components from both fruits under different processing conditions.
- The research found unique markers in lime juices and confirmatory methods combining H-NMR spectroscopy with HPLC data could distinguish between juice qualities affected by mechanical stress.