- Sacubitril/valsartan significantly improves outcomes in patients with chronic heart failure and reduced ejection fraction, enhancing left ventricular (LV) function over six months of treatment.
- Key improvements were observed, including increased LV contractility (Ees), decreased afterload (Ea), and enhanced ventricular-arterial coupling ratio (Ea/Ees), along with a notable increase in left ventricular ejection fraction (LVEF) from 33% to 43%.
- The study found positive correlations between changes in LVEF and LV contractility, as well as between NT-proBNP levels and left ventricular end-diastolic pressure (LVEDP), suggesting these factors play a role in the treatment's effectiveness