Effects of drug efflux on convection-enhanced paclitaxel delivery to malignant gliomas: technical note.

Objective: Convection-enhanced delivery (CED) is an approach in local brain tumor treatment. The spread of infusate in CED can be thought of as involving three phases: backflow, convection, and diffusion. Uncontrolled backflow may lead to efflux of the infusate outside the cranium.