Publications by authors named "Philip Ta"
Article Synopsis
- * The drug caused significant fungal kills, achieving fungicidal effects (>3 log) at various concentrations, and demonstrated post-antifungal effects (PAFEs) that prolonged its activity even after short exposure.
- * Additionally, PAFE experiments revealed that micafungin induced cell wall damage, decreased the fungi's ability to adhere to cells, and made them more susceptible to being attacked by immune cells (mac
Article Synopsis
- Anidulafungin is an antifungal drug that targets the cell walls of Candida species by blocking beta-1,3-glucan synthase, leading to cell death and lasting effects even after the drug is removed.
- In experiments, anidulafungin showed significant fungicidal activity against various Candida isolates, with impressive results at high concentrations (MICs) resulting in effective cell kill and prolonged inhibition of regrowth for over 12 hours.
- The drug also caused changes in cell wall structure and reduced the ability of Candida to adhere to human cells, suggesting that its effectiveness comes not only from killing the fungi directly but also by making it harder for the pathogens to infect and survive in hosts.