Publications by authors named "Philip Rawson-Harris"
Intern Med J
November 2024
Article Synopsis
- * Out of 273 patients, 46 (16.9%) had methicillin-resistant S. aureus (MRSA), with higher prevalence in those who injected drugs in the past 6 months (20.6% compared to 15.7% of other patients).
- * Injecting drug use was found to significantly increase the odds of having MRSA by 4.82 times, even after controlling for other factors.
Article Synopsis
- Critically ill patients often receive insufficient beta-lactam antibiotic doses due to physiological changes, which can lead to treatment failures or harmful side effects.
- The study aims to evaluate the feasibility and effectiveness of implementing therapeutic drug monitoring (TDM) for beta-lactam dosing in an intensive care setting, comparing TDM-guided dosing with standard care.
- The trial will assess recruitment feasibility, TDM fidelity, and monitor secondary outcomes like achieving dosing targets and the occurrence of drug-related toxicities.
