RONN: the bio-basis function neural network technique applied to the detection of natively disordered regions in proteins.

Motivation: Recent studies have found many proteins containing regions that do not form well-defined three-dimensional structures in their native states. The study and detection of such disordered regions is important both for understanding protein function and for facilitating structural analysis since disordered regions may affect solubility and/or crystallizability.

Results: We have developed the regional order neural network (RONN) software as an application of our recently developed 'bio-basis function neural network' pattern recognition algorithm to the detection of natively disordered regions in proteins.