Training future dental clinicians. An integrated approach to health care.

The next generation of dental professionals will require an improved understanding of the interplay between oral health and general health. An aging population, a greater proportion of medically complex patients and an evolving health care delivery system all call for changes in the ways dentists are trained. A concerted effort to broaden primary health-care activities in the dental office will greatly improve both oral and general health outcomes.

MuLK, a eukaryotic multi-substrate lipid kinase.

We report the identification and characterization of a novel lipid kinase that phosphorylates multiple substrates. This enzyme, which we term MuLK for multi-substrate lipid kinase, does not belong to a previously described lipid kinase family. MuLK has orthologs in many organisms and is broadly expressed in human tissues.

An outbreak of Rift Valley fever in Northeastern Kenya, 1997-98.

In December 1997, 170 hemorrhagic fever-associated deaths were reported in Garissa District, Kenya. Laboratory testing identified evidence of acute Rift Valley fever virus (RVFV). Of the 171 persons enrolled in a cross-sectional study, 31(18%) were anti-RVFV immunoglobulin (Ig) M positive.