Dietary protein splanchnic uptake and digestibility via stable isotope tracers.

Purpose Of Review: Dietary proteins are broken down into peptides across the gastrointestinal tract, with skeletal muscle being a primary deposition site for amino acids in the form of incorporation into, for example, metabolic and structural proteins. It follows that key research questions remain as to the role of amino acid bioavailability, of which protein digestibility and splanchnic sequestration (absorption and utilization) of amino acids are determining factors, impact upon muscle protein synthesis (MPS) in clinical states.

Recent Findings: Elevated splanchnic amino acid uptake has been implicated in anabolic resistance (i.

It's not just about protein turnover: the role of ribosomal biogenesis and satellite cells in the regulation of skeletal muscle hypertrophy.

Skeletal muscle has indispensable roles in regulating whole body health (e.g. glycemic control, energy consumption) and, in being central in locomotion, is crucial in maintaining quality-of-life.

Continuous hyperfractionated accelerated radiotherapy - Escalated dose (CHART-ED): A phase I study.

Introduction: Patients who present with locally advanced inoperable non-small cell lung cancer (NSCLC) may be suitable for radical radiotherapy. A randomised trial of 563 patients compared CHART and conventional radical radiotherapy (60 Gy/30f) given over 6 weeks and suggested that CHART resulted in a 9% improvement in 2-year survival (Saunders et al., 1999).

The mechanistic and ergogenic effects of phosphatidic acid in skeletal muscle.

Skeletal muscle mass plays a vital role in locomotion, whole-body metabolic health, and is a positive predictor of longevity. It is well established the mammalian target of rapamycin (mTOR) is a central regulator of skeletal muscle protein turnover. The pursuit to find novel nutrient compounds or functional food sources that possess the ability to activate mTOR and promote skeletal muscle protein accretion has been on going.

Is there an optimal time for warfighters to supplement with protein?

Although nutritional requirements for warfighters will inevitably vary in accordance with job role and active-inactive duty cycling, somewhat generic recommendations do still apply. In considering aspects of "optimal" nutrient timing, it is important to outline singular and combinatorial relationships between protein intake and physical activity (e.g.