Publications by authors named "Philip E Whalen"
Background: With the complexity of cancer treatment rising, the role of multidisciplinary conferences (MDCs) in making diagnostic and treatment decisions has become critical. This study evaluated the impact of a thoracic MDC (T-MDC) on lung cancer care quality and survival.
Methods: Lung cancer cases over 7 years were identified from the Roswell Park cancer registry system.
Properly timed exposure to central ANG II prevents behavioral sensitization and changes in angiotensin receptor expression.
Am J Physiol Regul Integr Comp Physiol
December 2014
Article Synopsis
- Previous studies show that the angiotensin type 1 receptor (AT1R) can quickly become desensitized to ANG II, but more extended exposure may lead to increased sensitivity or sensitization.
- In an experiment with rats, those that received a single injection of ANG II showed higher AT1R mRNA levels in certain brain regions compared to control groups, but similar effects were not seen with multiple injections.
- Behavioral tests indicated that one daily injection of ANG II heightened the thirst response, while four daily injections did not, suggesting that multiple dosing can prevent the typical receptor and behavioral sensitization associated with ANG II.