Publications by authors named "Philip Derleder"
Front Cell Neurosci
October 2024
Article Synopsis
- Noise-induced cochlear synaptopathy leads to the permanent loss of synapses between inner hair cells (IHCs) and spiral ganglion neurons (SGNs) without affecting overall hearing thresholds.
- In experiments with C57BL/6 N mice exposed to various noise levels, significant changes in auditory brainstem responses (ABRs) were observed, indicating loss of IHC synaptic connections and impaired hearing ability over time.
- The study revealed that while the number of synaptic pairs decreased significantly, the IHC postsynapses were more resilient than the presynaptic ribbons, highlighting the vulnerability of these synapses to noise trauma at high decibel levels.
