Magnetic nanoparticles as an orthogonal support of polymer resins: applications to solid-phase suzuki cross-coupling reactions.

[reaction: see text] Most of the reactants immobilized on conventional solid-phase resins are buried inside the interiors of lightly cross-linked polystyrene beads. An orthogonal support of solid-phase resins needs to be small enough to penetrate the interpolymeric chain spaces of a swollen resin to reach reaction sites. In this paper, we report the use of magnetic nanoparticles ( approximately 4 nm) as an orthogonal matrix to assist solid-phase reactions.

Recycling of homogeneous Pd catalysts using superparamagnetic nanoparticles as novel soluble supports for Suzuki, Heck, and Sonogashira cross-coupling reactions.

Recycling of homogeneous catalysts could be achieved by using magnetic nanoparticles and solid-phase beads, but nanoparticle-supported catalysis proceeded much faster than its counterpart on resins.

Superparamagnetic nanoparticle-supported enzymatic resolution of racemic carboxylates.

Candida rugosa lipase immobilized on maghemite nanoparticles demonstrated high stereoselectivity in kinetic resolution of racemic carboxylates and improved long-term stability over its parent free enzyme, allowing the supported enzyme to be repeatedly used for a series of chiral resolution reactions.

Superparamagnetic nanoparticle-supported catalysis of Suzuki cross-coupling reactions.

Emulsion polymerization was examined as a novel route for the synthesis of core/shell superparamagnetic nanoparticles consisting of a highly crystalline gamma-Fe2O3 core and a very thin polymeric shell wall. These nanoparticles were used as soluble supports for immobilizing Pd catalysts to promote Suzuki cross-coupling reactions. Recovery of catalysts was facilely achieved by applying a permanent magnet externally.