Publications by authors named "Philip D Mason"

Background: Despite an increasing awareness of the importance of innate immunity, the roles of natural killer (NK) cells in transplant rejection and antiviral and cancer immunity during immunosuppression have not been clearly defined.

Methods: To address this issue we have developed a quantitative assay of NK cell function that can be used on clinical samples and have studied the influence of immunosuppression on NK cell function. NK cell degranulation and intracellular interferon (IFN)-γ production were determined by flow cytometry of peripheral blood samples.

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Article Synopsis
  • Living donor kidney transplants generally result in better outcomes than deceased donor transplants, but results can vary significantly based on several factors.
  • An analysis of over 3,000 cases revealed that while patient survival is higher for related donors, graft survival is better for unrelated donors, although these differences diminished once other influencing factors were considered.
  • Key findings indicate that older donor age negatively impacts patient survival and that factors like recipient diabetes and gender also play a role, but the expected impact of HLA mismatches was not observed.
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