Publications by authors named "Philip Clay"
Trichloroethylene (TCE) has been reported to give a small, but significant, increase in renal tumours in the rat. These tumours were always associated with nephrotoxicity which is most likely caused by the metabolism of TCE to S-(1,2-dichlorovinyl)-L-cysteine (DCVC) which accumulates in the proximal tubules. The genotoxicity of TCE and DCVC have been evaluated in vivo using the comet assay to assess DNA breakage in the proximal tubules of rat kidneys.
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- The Mouse Lymphoma Assay (MLA) Workgroup, consisting of global experts, met on September 9, 2005, to reach consensus on the 24-hour treatment protocol in genotoxicity testing.
- Recommendations were made regarding acceptable values for negative and positive controls, including mutant frequency and cloning efficiency.
- The Workgroup supported the inclusion of 24-hour treatments without S-9 in the MLA assay when shorter treatments yielded negative results, aligning with International Committee on Harmonization guidelines.
Styrene monomer is a commercially important chemical used extensively in the production of plastics. It has been shown to induce lung tumours in the mouse via the inhalation route. Styrene monomer has shown a low reactivity with DNA and also a lack of genotoxic response in the mouse lung in vivo.
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