Effect of optical diagnosis training on recognition and treatment of submucosal invasive colorectal cancer in community hospitals: a prospective multicenter intervention study.

Background:  Recognition of submucosal invasive colorectal cancer (T1 CRC) is difficult, with sensitivities of 35 %-60 % in Western countries. We evaluated the real-life effects of training in the OPTICAL model, a recently developed structured and validated prediction model, in Dutch community hospitals.

Methods:  In this prospective multicenter study (OPTICAL II), 383 endoscopists from 40 hospitals were invited to follow an e-learning program on the OPTICAL model, to increase sensitivity in detecting T1 CRC in nonpedunculated polyps.

Standardised training for endoscopic mucosal resection of large non-pedunculated colorectal polyps to reduce recurrence (*STAR-LNPCP study): a multicentre cluster randomised trial.

Objective: Endoscopic mucosal resection (EMR) is the preferred treatment for non-invasive large (≥20 mm) non-pedunculated colorectal polyps (LNPCPs) but is associated with an early recurrence rate of up to 30%. We evaluated whether standardised EMR training could reduce recurrence rates in Dutch community hospitals.

Design: In this multicentre cluster randomised trial, 59 endoscopists from 30 hospitals were randomly assigned to the intervention group (e-learning and 2-day training including hands-on session) or control group.

Full-color optical combiner with good imaging quality and a wide angle of incident light acceptance.

This work demonstrates a full-color optical image combiner for augmented reality head-up displays. In this device, the angle of the incident light of the computer-generated image reflected by it can vary over a large range. It achieves improved performance by using a combination of polarization interference filters (PIFs), quarter-wave retarders (QWRs), and polarization volume holograms (PVHs).

Limited wedge resection for T1 colon cancer (LIMERIC-II trial) - rationale and study protocol of a prospective multicenter clinical trial.

Background: The sole presence of deep submucosal invasion is shown to be associated with a limited risk of lymph node metastasis. This justifies a local excision of suspected deep submucosal invasive colon carcinomas (T1 CCs) as a first step treatment strategy. Recently Colonoscopy-Assisted Laparoscopic Wedge Resection (CAL-WR) has been shown to be able to resect pT1 CRCs with a high R0 resection rate, but the long term outcomes are lacking.

Intuitive understanding of the connection between Pancharatnam-Berry optical beam deflectors and polarization volume holograms.

An approximate beam propagation method is proposed as an intuitive simulation of the optics of Pancharatnam-Berry phase and polarization volume hologram devices. Using this method, the connection between and polarization properties of these two types of devices are made clear.

Dynamic correction of astigmatism.

For the correction of defocus and astigmatism, mechanical approaches are well known, but there is a need for a non-mechanical, electrically tunable optical system that could provide both focus and astigmatism power correction with an adjustable axis. The optical system presented here is composed of three liquid-crystal-based tunable cylindrical lenses that are simple, low cost, and having a compact structure. Potential applications of the concept device include smart eyeglasses, virtual reality (VR)/ augmented reality (AR) head-mounted displays (HMDs), and optical systems subject to thermal or mechanical distortion.

Endoscopic intermuscular dissection for deep submucosal invasive cancer in the rectum: a new endoscopic approach.

Background: The risk of lymph node metastasis associated with deep submucosal invasion should be balanced against the mortality and morbidity of total mesorectal excision (TME). Dissection through the submucosa hinders radical deep resection, and full-thickness resection may influence the outcome of completion TME. Endoscopic intermuscular dissection (EID) in between the circular and longitudinal part of the muscularis propria could potentially provide an R0 resection while leaving the rectal wall intact.

Full-Thickness Scar Resection After R1/Rx Excised T1 Colorectal Cancers as an Alternative to Completion Surgery.

Introduction: Local full-thickness resections of the scar (FTRS) after local excision of a T1 colorectal cancer (CRC) with uncertain resection margins is proposed as an alternative strategy to completion surgery (CS), provided that no local intramural residual cancer (LIRC) is found. However, a comparison on long-term oncological outcome between both strategies is missing.

Methods: A large cohort of patients with consecutive T1 CRC between 2000 and 2017 was used.

Compensator design for polarization state management in waveguide displays based on polarization volume gratings.

In this work, we focus on the polarization state management in optical devices using optical elements based on circular polarization. As an example, we point out the issue in a waveguide display using circular polarization optical elements as input/output couplers, where the polarization state of the light can change as it propagates in the waveguide due to total internal reflection (TIR). This has a negative effect on the waveguide output coupler efficiency, image uniformity, and the polarization multiplexing capability.

Closer look at transmissive polarization volume holograms: geometry, physics, and experimental validation.

In this work, we took a closer look at transmissive polarization volume holograms (T-PVH) to provide clarifications on their geometry, physics, and optical responses by finite-difference time-domain (FDTD) simulation and experimental validation. First, we introduced the four possible geometries of T-PVH and simulated their optical responses in terms of diffraction efficiency, polarization selectivity, and polarization output. It is shown that the configuration we called "Slanted T-PVH (-/-+90)," where the director is perpendicular to the Bragg planes, has the advantageous property of maintaining circular output polarization states.

High-efficiency, tunable, fringe-field switching-mode beam steering based on a liquid crystal Pancharatnam phase.

We have fabricated, characterized, and analyzed a recently proposed non-mechanical beam steering device based on the Pancharatnam-Berry phase in a liquid crystal. The architecture of our proposed device employs a linear array of phase control elements (PCEs) to locally control the orientation of the liquid crystal director into a cycloidal pattern to deflect transmitted light. The PCEs are comprised of a fringe-field switching electrode structure that can provide a variable in-plane electric field.

Large area liquid crystal lenses for correction of presbyopia.

Presbyopia is the failure of the eye lens to accommodate. The widely used presbyopia correction method involves wearing bi/trifocal or progressive glasses, which limits the field of view due to division of lens area into sections of different optical power. A large aperture focus tunable liquid crystal lens has the potential to correct human eye accommodation failure and provide a wide field of view.

Design of a large aperture, tunable, Pancharatnam phase beam steering device.

Replacing mechanical optical beam steering devices with non-mechanical electro-optic devices has been a long-standing desire for applications such as space-based communication, LiDAR and autonomous vehicles. While promising progress has been achieved to non-mechanically deflect light with high efficiency over a wide angular range, significant limitations remain towards achieving large aperture beam steering with a tunable steering direction. In this paper, we propose a unique liquid crystal based Pancharatnam Phase Device for beam steering which can provide both tunability and a fast response times in a format scalable to large apertures.

Polarization-independent fast optical shutter with high transmission.

In this work, we designed a fast cholesteric shutter by switching the director between homeotropic and transient planar states. It is polarization independent, has sub-millisecond response time, high transmission in homeotropic state, and is highly reflective in the transient planar state. We also developed a driving waveform to achieve a long dark state of the device.

Design of a sensitive uncooled thermal imager based on a liquid crystal Fabry-Perot interferometer.

Microbolometers are the dominant technology for uncooled thermal imaging; however, devices based on a direct retardation measurement of a liquid crystal (LC) transducer pixel have been shown to have comparable sensitivity. In this paper, an approach for increasing LC transducer sensitivity utilizing an etalon structure is considered. A detailed design for an LC resonant cavity between dielectric mirrors is proposed and the performance is evaluated numerically.

Process for a Reactive Monomer Alignment Layer for Liquid Crystals Formed on an Azodye Sublayer.

In this work, the detailed studies of surface polymerization stabilizing liquid crystal formed on an azodye sublayer are presented. The surface localized stabilization is obtained by free-radical polymerization of a dilute solution of a bi-functional reactive monomer (RM) in a liquid crystal (LC) solvent. To optimize the process for surface localized stabilization, we investigate the effects of several process parameters including RM concentration in LC hosts, the types of materials (either RM or LC), the photo-initiator (PI) concentration, ultra-violet (UV) polymerization intensity, and the UV curing temperature.

Design of a large aperture tunable refractive Fresnel liquid crystal lens.

A large aperture tunable lens based on liquid crystals, which is considered for near-to-eye applications, is designed, built, and characterized. Large liquid crystal lenses with high quality are limited by very slow switching speeds due to the large optical path difference (OPD) required. To reduce the switching time of the lens, the thickness is controlled through the application of several phase resets, similar to the design of a Fresnel lens.

"Achromatic limits" of Pancharatnam phase lenses.

Lenses based on the Pancharatnam phase have the advantage of being thin and inexpensive. Unfortunately, their optical effect is strongly wavelength dependent, and their applications generally are limited by the requirement of a monochromatic source. However, low-power lenses based on the Pancharatnam phase can be considered for applications over the visible range.

Flexoelectric in-plane switching (IPS) mode with ultra-high-transmittance, low-voltage, low-frequency, and a flicker-free image.

The demands for a power-saving mode for displaying static images are ubiquitous not only in portable devices but also in price tags and advertising panels. At a low-frequency driving in liquid crystal displays (LCDs) for low-power consumption, the flexoelectric effect arises even in calamitic liquid crystals and the optical appearance of this physical phenomenon is found to be unusually large, being noticed as an image-flickering. Although the inherent integrated optical transmittance of in-plane switching (IPS) mode is relatively lower than that of fringe-field switching (FFS) mode, the IPS mode shows no static image-flickering but an optical spike (the so-called optical bounce), at the transient moment between signal positive and negative frames.

High-efficiency large-angle Pancharatnam phase deflector based on dual-twist design.

We have previously shown through simulation that an optical beam deflector based on the Pancharatnam (geometric) phase can provide high efficiency with up to 80° deflection using a dual-twist structure for polarization-state control [Appl. Opt.54, 10035 (2015)].

Field-symmetrization to solve luminance deviation between frames in a low-frequency-driven fringe-field switching liquid crystal cell.

The development of low-frequency-driven liquid crystal displays (LCDs) has recently received intense attention to open up low-power consumption display devices, such as portable displays, advertising panels and price tags. In fringe-field switching (FFS) LCD mode, a unidirectional electric field gives rise to head-tail symmetry breaking in liquid crystals, so that the flexoelectric effect, a coupling between the elastic distortion and the electric polarization, becomes enormously significant. The effect is thus linked to an unusual optical effect, which badly damages the quality of images by image-flickering, and this image-flickering is mainly caused by transmittance difference between the applied signal frames.

Flexoelectric effect in an in-plane switching (IPS) liquid crystal cell for low-power consumption display devices.

Technology of displaying static images in portable displays, advertising panels and price tags pursues significant reduction in power consumption and in product cost. Driving at a low-frequency electric field in fringe-field switching (FFS) mode can be one of the efficient ways to save powers of the recent portable devices, but a serious drop of image-quality, so-called image-flickering, has been found in terms of the coupling of elastic deformation to not only quadratic dielectric effect but linear flexoelectric effect. Despite of the urgent requirement of solving the issue, understanding of such a phenomenon is yet vague.

Nonmechanical zoom lens based on the Pancharatnam phase effect.

We present a nonmechanical zoom lens system based on the Pancharatnam phase effect, which is controlled by the state of circularly polarized light. The device is shown to allow for a compact design for a wide range of zoom ratios. A demonstration system is shown, which has a 4× zoom ratio between its two electrically switchable states.