Publications by authors named "Philip B Sugerman"
Article Synopsis
- - The study analyzed the epidemiology and economic impact of atopic dermatitis (AD) in Israel using a healthcare database from 2008 to 2017, finding an AD incidence of 7.0 per 1,000 person-years and a prevalence of 4.4% overall.
- - Results showed that AD severity was categorized as mild (57.7%), moderate (36.2%), and severe (6.1%), with a notable portion of patients visiting dermatologists and allergists, and hospitalization rates also reported.
- - The findings indicate that individuals with AD incur significantly higher healthcare costs—an increase of 36% for overall costs and 52% for moderate-to-severe cases—compared to controls
Background: Patients with atopic dermatitis (AD) are susceptible to infectious and inflammatory cutaneous comorbidities.
Objective: The aim of the study was to describe the prevalence of cutaneous comorbidities associated with AD, including their relationship with AD severity.
Methods: A retrospective cross-sectional analysis was performed using the Israeli Maccabi Healthcare Services database.
Current controversies in oral lichen planus: report of an international consensus meeting. Part 2. Clinical management and malignant transformation.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
August 2005
Article Synopsis
- Recent progress has been made in understanding oral lichen planus (LP), but the exact causes and pathways of lesion formation are still unclear, creating challenges for clinical treatment.
- A consensus meeting in France in March 2003 addressed key issues, particularly the links between oral LP and viral infections like hepatitis C virus (HCV), as well as the immune mechanisms involved in the disease.
- The second part of the meeting report dealt with patient management strategies and treatment options, including concerns about the potential for malignant transformation of oral LP.
Current controversies in oral lichen planus: report of an international consensus meeting. Part 1. Viral infections and etiopathogenesis.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
July 2005
Article Synopsis
- Recent advances have improved knowledge of oral lichen planus (LP), but the exact triggers for lesions and key pathogenic pathways remain unclear.
- A 2003 consensus meeting in France explored controversial topics related to oral LP, highlighting its possible connection to hepatitis C virus and the immune responses that lead to cellular damage.
- The meeting also addressed how to manage patients with oral LP, including treatment options and concerns about the potential for malignant transformation.
The kinetics of gene expression associated with the development of cutaneous graft-versus-host disease (GVHD) were examined in a mouse model of MHC-matched allogeneic hematopoietic stem cell transplantation. Ear skin was obtained from recipient mice with or without GVHD between 7 and 40 days after transplantation for histopathological analysis and gene expression profiling. Gene expression patterns were consistent with early infiltration and activation of CD8(+) T and mast cells, followed by CD4(+) T, natural killer, and myeloid cells.
View Article and Find Full Text PDFBackground: Cell-mediated immune responses in oral lichen planus (OLP) may be regulated by cytokines and their receptors.
Methods: In situ cytokine expression and in vitro cytokine secretion in OLP were determined by immunohistochemistry and ELISA.
Results: The majority of subepithelial and intraepithelial mononuclear cells in OLP were CD8+.
Patient selection for endosseous dental implants: oral and systemic considerations.
Int J Oral Maxillofac Implants
July 2002
This paper reviews the literature and discusses patient selection for endosseous dental implants and the effect of systemic and local pathology on the success rate of dental implants. Endosseous dental implants may be preferable to conventional dentures in patients with compromised supporting bone or mucosa, xerostomia, allergy to denture materials, severe gag reflex, susceptibility to candidiasis, diseases affecting orofacial motor function or in patients who demand optimal bite force, esthetics, and phonetics. Conventional dentures or fixed partial prostheses may be preferable to endosseous dental implants in growing and epileptic patients and patients at risk of oral carcinoma, anaphylaxis, severe hemorrhage, steroid crisis, endocarditis, osteoradionecrosis, myocardial infarction, or peri-implantitis.
View Article and Find Full Text PDFBackground: We investigated basement membrane (BM) disruption and the distribution of mast cells (MCs) and T cell subsets, in oral lichen planus (OLP) and normal buccal mucosa (NBM) using immunohistochemistry. In OLP, there were increased numbers of tryptase+ MCs in areas of BM disruption (P < 0.05).
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