Publications by authors named "Philip Adam Kramer"
Nephrotoxicity is a significant concern during the development of new drugs or when assessing the safety of chemicals in consumer products. Traditional methods for testing nephrotoxicity involve animal models or 2D in vitro cell cultures, the latter of which lack the complexity and functionality of the human kidney. 3D in vitro models are created by culturing human primary kidney cells derived from urine in a 3D microenvironment that mimics the fluid shear stresses of the kidney.
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- Researchers discovered that mitochondrial dysfunction in blood cells can indicate cognitive decline in Alzheimer's disease (AD) patients.
- The study found that people with dementia had the lowest mitochondrial function in their blood cells, while those with mild cognitive impairment (MCI) showed higher oxygen use compared to healthy individuals.
- Blood-based assessments of mitochondrial function could serve as a non-invasive method to track bioenergetic changes related to AD risk and progression over time.