Publications by authors named "Phil Stafford"
Older adults and those living in rural areas face unique challenges to health and food security which were exacerbated during the COVID-19 pandemic. We examine the interrelationships among food security, physical health, and loneliness among rural older adults before the onset of and during the COVID-19 pandemic. Using data from a cross-sectional household survey of older adults in rural Indiana, administered May 2020 through July 2020, our results show a higher prevalence of food insecurity, poorer physical health, and increased loneliness after the onset of the pandemic.
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- KRAS mutations are key drivers in pancreatic ductal adenocarcinoma (PDAC), but about 10.7% of PDAC cases are KRAS wild-type (WT), prompting the need to analyze their unique molecular features for new treatment options.
- In a study involving 2,483 patients, KRAS WT PDAC tumors frequently showed mutations in genes like TP53 and alterations in DNA-damage repair and cell-cycle control pathways, indicating potential targets for therapy.
- KRAS WT tumors displayed higher rates of microsatellite instability and tumor mutational burden, along with a survival advantage for patients when treated with specific chemotherapies, suggesting that identifying these patients could enhance treatment strategies.