Clinical management. Where medicine meets management. Muscle power.

Physiotherapy-led services can dramatically cut orthopaedic waiting times, improve patient choice and reduce GP workload. Waiting times are cut by reducing the number of unnecessary referrals. Providing more direct access to physiotherapy services is key.

Nuclear factor kappaB inhibitors induce adhesion-dependent colon cancer apoptosis: implications for metastasis.

The transcription factor nuclear factor kappaB (NFkappaB) is constitutively active in many types of cancercells and regulates the expression of several antiapoptotic genes. Previous studies demonstrated a role for the inhibition of NFkappaB in cancer therapyusing a transgenic approach in mice. We found that NFkappaB was transiently activated much greater than background constitutive levels during colon cancer cell readhesion, which rendered the readhering colon cancer cells exquisitely susceptible to apoptosis in the presence of soluble NFkappaB inhibitors.