Publications by authors named "Phil Czerniak"
J Pharmacol Exp Ther
July 2011
Article Synopsis
- CCR5 is a key target for inhibiting HIV-1 and has potential in treating inflammatory diseases, with the study focusing on a specific inhibitor, INCB9471.
- INCB9471 has shown safety and effectiveness in reducing viral load in human clinical trials and works by preventing monocyte migration and infection by R5-HIV-1 strains.
- Comparisons indicate that INCB9471's potency in blocking CCR5 is similar to other clinical antagonists, suggesting its promising role in HIV treatment.
