Publications by authors named "Phi-Nga Jeannie Le"

Article Synopsis
  • Research examines how tunnel workers experience high pressure exposure compared to SCUBA divers, focusing on inflammation linked to decompression sickness (DCS).
  • Despite longer high-pressure exposure in tunnel workers (4.1-4.9 hours) versus shorter exposure for divers (0.61 hours), blood analysis showed similar increases in blood microparticles and interleukin levels for both groups.
  • Neutrophil counts and activation were significantly higher in tunnel workers, indicating that while microparticle levels stabilize quickly, neutrophil activation requires more time under high pressure conditions.
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The authors describe an innovative wound score and demonstrate its versatility for scoring a variety of wound types in addition to diabetic foot ulcers (DFUs). To further test its merits, they determined its interobserver reliability in a prospective series of patients. The Wound Score system the authors created integrates the most important features of 4 predominantly used wound scoring systems.

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Decompression sickness (DCS) is a systemic disorder, assumed due to gas bubbles, but additional factors are likely to play a role. Circulating microparticles (MPs)--vesicular structures with diameters of 0.1-1.

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Recent innovations in the field of wound healing have created numerous advanced therapies from which clinicians may now choose. The challenge for the reconstructive surgeon is to ensure that these adjunct technologies are used according to an evidence-based protocol to ensure optimal healing. Critical to successful outcomes is that new modes of therapy do not supplant, but are used in tandem with, core principles of wound management: establishing a correct diagnosis, ensuring a good local blood supply, debriding the wound to a clean base, correcting the biomechanical abnormality, and nurturing the wound until it shows signs of healing.

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