Effects of 100 IU versus 150 IU hCG supplementation on oocyte and embryo quality in patients aged ≥ 35 years: a propensity score-matched analysis.

The optimal dose of human chorionic gonadotropin (hCG) supplementation during controlled ovarian stimulation (COS) remains controversial, particularly in women of advanced reproductive age. To compare the efficacy and safety of 150 IU versus 100 IU daily hCG supplementation from stimulation day 6 in women aged ≥ 35 years undergoing fertilization/intracytoplasmic sperm injection (IVF/ICSI). In this retrospective cohort study, we analyzed data from 438 patients aged ≥ 35 years undergoing IVF at a single center.

Fewer good-quality cleavage embryos in dydrogesterone-primed ovarian stimulation compared to GnRH antagonist protocol in POSEIDON group 4 patients.

Objective: To compare the in vitro fertilization (IVF) outcomes of the progestin-primed ovarian stimulation (PPOS) protocol using dydrogesterone and the GnRH antagonist (GnRH-ant) protocol in POSEIDON group 4 patients.

Methods: This retrospective cohort study analyzed 447 POSEIDON group 4 patients who underwent IVF at a single center. Patients were categorized into GnRH-ant (n = 281) and PPOS (n = 166) groups.