Monoclonal antibody specific to the Di blood group antigen generated by phage display technology.

Background: Alloanti-Di can be implicated in mild to severe blood transfusion reactions. Given the concomitance of a high prevalence of the Di antigen and antibody circulating in some populations, an anti-Di typing reagent is required in order to enable safe blood transfusions. Limitations of hybridoma technology to produce such a reagent led to the use of phage display technology to generate an anti-Di monoclonal antibody.

and Allele Frequencies Among Southern Thai Blood Donors.

Diego (DI) blood group genotyping is clinically important in Asian populations. Data of Diego blood type among southern Thais is still unknown. This study aimed to report and allele frequencies in southern Thai blood donors and to estimate potential risk of Di incompatibility and alloimmunization in Thai populations.

Distribution of DI*A and DI*B Allele Frequencies and Comparisons among Central Thai and Other Populations.

Alloantibodies to the Diego (DI) blood group system, anti-Dia and anti-Dib are clinically significant in causing hemolytic transfusion reactions (HTRs) and hemolytic disease of the fetus and newborn (HDFN), especially in Asian populations with Mongolian ancestry. This study aimed to report the frequency of the DI*A and DI*B alleles in a Central Thai population and to compare them with those of other populations previously published. Altogether, 1,011 blood samples from unrelated healthy blood donors at the National Blood Centre, Thai Red Cross Society, Bangkok were included.