Publications by authors named "Phan Thi Phuong Trinh"
Background: Preterm infants are more likely to experience severe respiratory syncytial virus (RSV) disease compared to term infants. The reasons for this are multi-factorial, however their immature immune system is believed to be a major contributing factor.
Methods: We collected cord blood from 25 preterm (gestational age 30.
Article Synopsis
- Preterm infants are more vulnerable to severe infections than full-term infants, possibly due to their ability to respond to pathogens, with limited research on their viral response specifically.
- The study examined immune responses in cord blood mononuclear cells from preterm and term infants, comparing their reactions to various Toll-like receptor (TLR) agonists, revealing similar baseline TLR expression but different activation patterns.
- While both preterm and term infants displayed comparable responses, preterm infants had increased monocyte activation to certain bacterial stimuli, but did not match the higher levels of immune response seen in adults, indicating a need for further research to address infection risks in preterm infants.
Background: Preterm infants are highly vulnerable to infectious disease. While many factors are likely to contribute to this enhanced susceptibility, the immature nature of the preterm immune system is postulated as one key factor.
Methods: In our study, we used high-dimensional flow cytometry and cytokine assays to characterise the immune profiles in 25 preterm (range: 30.