Two New Steroidal Saponins with Potential Anti-Inflammatory Effects from the Aerial Parts of Markgr.

Markgr., a member of the Gnetaceae family, is distributed in Vietnam. This plant remains a botanical enigma with an unexplored diversity of chemical constituents and pharmacological effects.

Withaperuvin O, a new withanolide from L.

L. (Solanaceae) has been used in tropical and subtropical countries of the world as medicinal and fruit trees. In this study, a new withanolide named withaperuvin O () and seven known ones, including physalolactone B-3-O--D-glucopyranoside (), withanolide J (), physapruin A (), physaperuvin G (), withaperuvin (), withaperuvin C () and 28-hydroxywithaperuvin C (), were isolated from the whole plants of .

Alpha-Glucosidase Inhibitory Activity of Saponins Isolated from Hance.

Species belonging to the (Asteraceae), the largest genus in the tribe Vernonieae (consisting of about 1,000 species), are widely used in food and medicine. These plants are rich sources of bioactive sesquiterpene lactones and steroid saponins, likely including many as yet undiscovered chemical components. A phytochemical investigation resulted in the separation of three new stigmastane-type steroidal saponins (1 - 3), designated as vernogratiosides A-C, from whole plants of .

Isolation, structural elucidation and molecular docking studies against SARS-CoV-2 main protease of new stigmastane-type steroidal glucosides isolated from the whole plants of .

Phytochemical investigation of the whole plants of Hance. led in the isolation and identification of two new stigmastane-type steroidal glucosides (-), namely vernogratiosides A (), and B (). Their chemical structures were fully elucidated based on 1 D/2D NMR spectroscopic, HR-ESI-MS data analyses, and by producing derivatives by chemical reactions.

Metabolism of Diterpenoids Derived from the Bark of in Human Liver Microsomes.

L. is used as a spice and flavoring agent as well as a traditional medicine worldwide. Diterpenoids, a class of compounds present in  , have various pharmacological effects, such as anti-inflammatory, antitumor, and antibacterial activities; however, there are insufficient studies on the metabolism of diterpenoids.