Isoryanodane diterpene derivatives from .

From the MeOH residue of branches and leaves, one new isoryanodane diterpene, barringisol (), and two new isoryanodane diterpene glucosides, barringisosides A and B ( and ), were obtained using various chromatographic isolations. The structural characterization was confirmed by spectroscopic methods including 1D, 2D NMR and HR-ESI-QTOF-MS. This is the first isolation of isoryanodane diterpene derivatives from species.

Dammarane-type triterpenoid saponins from the flower buds of with cytotoxic activity.

Phytochemical investigation of a methanol extract of flower buds resulted in the isolation of 22 dammarane-type triterpenoid saponins, including three new compounds, pseudoginsenosides A-C (-), and 19 known analogs. Their chemical structures were identified by the comprehensive spectroscopic methods, including 1 D and 2 D NMR and mass spectra. In addition, their cytotoxic effects toward three human carcinoma cell lines, including liver (HepG2), breast (MCF7), and lung (A549) were also evaluated.

Chemical constituents from and their anti-inflammatory and cytotoxic activities.

Phytochemical investigation of the whole plants of resulted in the isolation and identification of three new compounds (-), namely lycocernuaside E (), lycernuic ketone F (), and lycernuic B () and 12 known ones (-). Their chemical structures were established based on 1 D/2D NMR spectroscopic and HR-ESI-MS data analyses. Compounds , , and displayed NO inhibitory effects in LPS-stimulated BV2 cells, with IC values of 21.

Diterpenoids and Flavonoids from Andrographis paniculata.

Chemical investigation of the aerial parts of Andrographis paniculata resulted in isolation of nine compounds, including a new ent-labdane diterpenoid, andrographic acid methyl ester (1), a new chalcone glucoside, pashanone glucoside (5), and seven known metabolites, andrograpanin (2), andrographolide (3), andropanolide (4), andrographidine A (6), andrographidine F (7), 6-epi-8-O-acetyl-harpagide (8), and curvifloruside F (9). Their chemical structures were elucidated based on comprehensive analyses of the spectroscopic data, including NMR and MS. Among the isolated compounds, andropanolide exerted cytotoxicity toward LNCaP, HepG2, KB, MCF7, and SK-Mel2 carcinoma cells, with IC values ranging from 31.

Sulphated flavones and pregnane-type steroids from .

In our search for anti-inflammatory constituents from Vietnamese plants, the methanolic extract of was found to exhibit inhibitory effect on LPS-induced NO production in RAW264.7 cells. Phytochemical investigation of this plant led to isolation of four sulphated flavones (), including one new compound 5,3',4'-trihydroxy-7-methoxy-8--sulphate flavone (), and two pregnane-type steroids ( and ), including one new compound 7--heligenin B ().

Sesquiterpenoids from .

Sixteen sesquiterpenoids (-), including two new compounds namely saussucostusosides A and B ( and ), were isolated from the roots of by various chromatographic separations. Their structures were elucidated by 1 D and 2 D NMR and HR-QTOF-MS experiments. Among isolated compounds, costunlide (), 3-[4-hydroxymethacryloyloxy]-8-hydroxycostunolide () and 11,13-dihydrozaluzanin C () exhibited potent inhibitory effects on LPS-induced NO production in RAW264.