Publications by authors named "Pham Quang Tho"

Background: Stroke recurrence and disability are important challenges to overcome in patients with minor ischemic stroke. The aim of our study was to determine the factors associated with unfavorable outcomes in patients with minor ischemic stroke.

Methods: This was a prospective cohort study including patients with minor ischemic stroke with a National Institutes of Health Stroke Scale (NIHSS) score ≤ 4 who were treated at the Bach Mai Hospital stroke center from June 15, 2021, to September 15, 2022.

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Hemorrhagic stroke due to ruptured brain arteriovenous malformations (AVMs) is a common cause in young stroke patients. When the ruptured AVMs are in deep location, the choice of endovascular intervention with the arterial approach to AVM embolization is routine but in many cases, it is not feasible due to the inability to access because of the small and tortuous arterial branch, however, the intravenous approach also results in high complete obliteration rates but also carries a higher risk of stroke than the intra-arterial route. We describe a 36-year-old female patient diagnosed with intracranial and intraventricular hemorrhage who underwent complete transvenous embolization of the ruptured AVMs, and achieved near-complete clinical recovery after 1 month with the modified Rankin scale 1.

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Article Synopsis
  • The study explores the effectiveness of low-dose versus standard-dose intravenous alteplase as bridging therapy before mechanical thrombectomy (MTE) in patients with large-vessel occlusion acute ischemic stroke (LVO-AIS).
  • A total of 107 patients were analyzed, with no significant differences in functional independence, recanalization rates, and complications between the low-dose (0.6 mg/kg) and standard-dose (0.9 mg/kg) alteplase groups at 90 days post-stroke.
  • The findings suggest that low-dose alteplase can achieve similar clinical outcomes compared to standard-dose alteplase in this setting, providing insights into treatment options and affordability for stroke patients.
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