Potentiation of Tumor Hallmarks by the Loss of GULO, a Vitamin C Biosynthesis Gene in Humans.

Vitamin C plays a significant role in various physiological functions. Humans depend on external sources of vitamin C due to the loss of the L-gulono-γ-lactone oxidase (GULO) gene that contributes to the synthesis of vitamin C. During the evolutionary loss of the GULO gene, physical, chemical, and biological factors were different from the present environmental settings.

Indian Hand Anthropometry: First Web Space Angle Measurement in A Population of 800 Subjects.

 The first web space of the hand plays a crucial role in determining the hand's span. Our study aims to examine and quantify the first web space angle in both hands of adult individuals within the Indian population with no upper limb pathologies. The primary objective of this study is to establish normative data.

Gait variability and biomechanical distinctions in knee osteoarthritis: Insights from a 3D analysis in an adult elderly cohort.

Background: This study employs 3D gait analysis to investigate normal gait patterns in individuals afflicted with knee Osteoarthritis (OA). Focusing on the adult osteoarthritic population, the research aims to establish reference values for joint angles, temporospatial parameters, Gait Profile Score (GPS), and Movement Analysis Profile (MAP) collected concurrently along a standardized walking path. Furthermore, the study delves into potential variations linked to gender and OA severity, comparing gait parameters between male and female participants and among individuals with grade 3 and grade 4 OA.

Effect of total knee arthroplasty on contralateral knee: A prospective comparative gait analysis of non-operated legs in the Indian population.

Introduction: Biomechanics plays a crucial function in osteoarthritis. Changes in the biomechanical parameters of the contralateral knee following total knee arthroplasty (TKA) may result in pain in the contralateral knee. The objective of this study was to examine preoperative and postoperative gait measurements on the contralateral leg following a TKA for a variety of gait measures at a self-selected normal gait pace in a similar speed population.

Tuberculosis of hand and wrist: Varied clinical presentation and functional outcome by surgical intervention in 13 cases.

A prospective study of 13 cases with tuberculosis of hand and wrist was presented with mean age of patients being 42.7 years (range 18 months to 84 years). Pain, swelling and difficulty in movement of adjacent joints were the most common presenting complaints.

Nfe2l2 Regulates Metabolic Rewiring and Epigenetic Reprogramming in Mediating Cancer Protective Effect by Fucoxanthin.

Fucoxanthin (FX) is a carotenoid with many pharmaceutical properties due to its antioxidant/anti-inflammatory and epigenetic effects. NFE2L2 is involved in the defense against oxidative stress/inflammation-mediated diseases, like anticancer effects elicited by phytochemicals including FX. However, the role of FX and NFE2L2 in metabolic rewiring, epigenomic reprogramming, and transcriptomic network in blocking pro-tumorigenic signaling and eliciting cancer-protective effects remains unknown.

Telehealth for consultation and shoulder rehabilitation: a preliminary study on the perspectives of 30 patients during the COVID-19 lockdown.

Background: This study aimed to determine: the perspectives of the patient cohort that underwent telehealth consultation and shoulder rehabilitation during coronavirus disease 2019 (COVID-19) and the differences in the patients' perspectives with the two different telehealth video applications (apps) used in the study.

Methods: This is a prospective study carried out during the COVID lockdown period of April to July 2020. Thirty consecutive patients from the orthopedics department of a tertiary institute in India underwent their first-ever session of a video app-based (Zoom or WhatsApp) telehealth consultation with shoulder rehabilitation exercises on a handheld mobile, tablet, or laptop device.

Revisiting the rotator cuff footprint.

Unlabelled: Newer studies challenged the traditionally held belief that the supraspinatus inserts on the entire superior facet and the infraspinatus is attached on the entire middle facet of the greater tuberosity. They showed that the infraspinatus tendon is thicker anteriorly and can be differentiated from the posterior part of the supraspinatus. Hence, the newer studies showed that the supraspinatus attached in a much smaller area than previously thought, and infraspinatus occupied the lateral part of the superior facet of the greater tuberosity.

Instability, complications, and functional outcomes after reverse shoulder arthroplasty and anatomic shoulder arthroplasty for chronic neglected shoulder dislocation: a systematic review.

Background: Chronic shoulder dislocation has been treated by either anatomic shoulder arthroplasty (ASA) or reverse shoulder arthroplasty (RSA) with encouraging results. Although good results have been reported after both the procedures, several complications such as instability and glenoid failures have also been highlighted. The aim of this study was to aggregate the results that have been reported with the use of ASA or RSA in chronic shoulder dislocation and analyze the instability rates, complication rates, and functional outcomes.

Results and complications of head-preserving techniques in chronic neglected shoulder dislocation: a systematic review.

Background: Humeral head-preserving procedures may be needed for chronic neglected shoulder dislocation because the presenting age of the patient is often reported to be less than 45 years. The aim of this systematic review was to evaluate the results of the various head-preserving procedures for chronic anterior dislocation (CAD) and chronic posterior dislocation (CPD). This review also aimed to evaluate the results of conservative neglect for CAD.

Role of Scale Wettability on Rain-Harvesting Behavior in a Desert-Dwelling Rattlesnake.

During storms in the southwestern United States, several rattlesnake species have been observed drinking rain droplets collected on their dorsal scales. This process often includes coiling and flattening of the snake's body, presumably to enhance water collection. Here, we explored this rain-harvesting behavior of the Western Diamond-backed Rattlesnake () from the perspective of surface science.

Droplet-train induced spatiotemporal swelling regimes in elastomers.

In this work, we perform a combined experimental and numerical analysis of elastomer swelling dynamics upon impingement of a train of solvent droplets. We use time scale analysis to identify spatiotemporal regimes resulting in distinct boundary conditions that occur based on relative values of the absorption timescale and the droplet train period. We recognize that when either timescale is significantly larger than the other, two cases of quasi-uniform swelling occur.

Dropwise Condensation on Soft Hydrophobic Coatings.

Promoting dropwise condensation (DWC) could improve the efficiency of many industrial systems. Consequently, a lot of effort has been dedicated to finding durable materials that could sustainably promote DWC as well as finding routes to enhance the heat transfer rate during this phase change process. Motivated by previous reports of substrate softening increasing droplet nucleation rate, here we investigated how mechanical properties of a substrate impact relevant droplet-surface interactions and DWC heat transfer rate.

Numerical investigation of thermal response of laser-irradiated biological tissue phantoms embedded with gold nanoshells.

The work presented in this paper focuses on numerically investigating the thermal response of gold nanoshells-embedded biological tissue phantoms with potential applications into photo-thermal therapy wherein the interest is in destroying the cancerous cells with minimum damage to the surrounding healthy cells. The tissue phantom has been irradiated with a pico-second laser. Radiative transfer equation (RTE) has been employed to model the light-tissue interaction using discrete ordinate method (DOM).

Regulation of Bach2 by the aryl hydrocarbon receptor as a mechanism for suppression of B-cell differentiation by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Exposure to the aryl hydrocarbon receptor (AHR) agonist, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) alters B-cell differentiation and suppresses antibody production. Previous genomic studies in mouse B cells identified Bach2 as a direct target of the AHR. Bach2 is known to repress expression of Prdm1, a key transcription factor involved in B-cell differentiation, by binding to Maf elements (MAREs) in the regulatory regions of the gene.

Differential regulation of centrosome integrity by DNA damage response proteins.

MDC1 and BRIT1 have been shown to function as key regulators in response to DNA damage. However, their roles in centrosomal regulation haven't been elucidated. In this study, we demonstrated the novel functions of these two molecules in regulating centrosome duplication and mitosis.

Avulsion of the fibular head post-total knee replacement.

We report a case of an avulsion of part of the fibular head during a primary total knee replacement for osteoarthritis. Post-operatively the patient developed a foot-drop. However, there was no clinically demonstrable instability of the knee.

QSAR study on toxicity to aqueous organisms using the PI index.

We have attempted to develop quantitative structure-toxicity relationships (QSTRs) to predict hydrophobicity (logP) as well as toxicity (pEC50 microm) of benzene derivatives using recently introduced Padmakar-Ivan (PI) index. The results have shown that both logP as well as pEC50 of benzene derivatives can be modelled excellently in multiparametric models in that the PI index and some indicator parameters are involved. The predictive ability of the models is discussed on the basis of the cross-validation method.

CHEMICAL CHARACTERISATION OF BHUIAVALI (Phyllanthus niruri).

The present article describes the chemical characteristics such as pH of aqueous extract, fluorescence, aqueous and alcoholic extractives, lignans and TLC profile of aqueous extract of Bhuiavli (Phyllanthus niruri).

Study of growth cycle of bhuiavli (phyllanthus nirur) and its phytochemistry during growth.

In view of the growing interest in Phyllanthus niruri, it was felt necessary to undertake a study of the growth cycle of the herb along with qualitative phytochemical observation in terms of active principle, its distribution in different parts of the plant and effect of storage and the active principle. The main purpose of the study was to develop guidelines for cultivation of the plant, rich in the active principle.

Action of some new insect growth regulators on mosquito vectors. Part II: Geraniol based diethers.

Biological activity of saturated diethers viz. 1-benzyloxy/phenoxy-8-alkoxy and 1-alkoxy-8-benzyloxy-3,7-dimethyl-1, 8-octanes (IIa-IIq) prepared from Geraniol, were studied on three mosquito species and the bug Dysdercus koenigii. These diethers exhibited oviposition deterrent and developmental inhibition activities of greater magnitudes than the compounds based on citronellol reported in Part I of this paper.