Effect of the combination of a crosslinking agent and a thiourethane additive on the properties of acrylic denture bases processed with microwave energy.

Thiourethane (TU) additives and difunctional, polymerizable crosslinking agents have been demonstrated to increase toughness in methacrylate-based materials. The aim of this study was to evaluate the potential reinforcement of acrylic denture bases by combining thiourethane additives and 1,6 hexanediol dimethacrylate (HDDMA) as an additional crosslinking agent. One commercial acrylic resin (Nature-Cryl MC; GC America) was tested by adding 0 (control) or 10 wt% TU, each of them combined with 0 (control), 10, 20 and 30 wt% HDDMA, for a total of 8 experimental groups.

Normative Yo-Yo Intermittent Recovery Level 1 and Yo-Yo Intermittent Endurance Level 1 test values of boys aged 9-16years.

Objectives: To provide age- and sex-specific reference values of Yo-Yo tests in children and adolescents.

Design: Systematic review.

Methods: A literature search for articles on Yo-Yo Intermittent (YYI) tests was performed in MEDLINE, SPORTDiscus, Web of Science and Google Scholar.

Imaging findings of Menkes disease, a radiographic mimic of abusive trauma.

Menkes disease is a rare X-linked recessive disorder caused by impaired copper absorption and transport. Presented here is a case of a 12-week-old male who presented with hypotonia and multiple metaphyseal fractures. Further imaging and workup revealed a diagnosis of Menkes disease.

Gray Matter Correlates of Creativity in Musical Improvisation.

Creativity has been defined as requiring both novelty and effectiveness, but little is known about how this standard definition applies in music. Here, we present results from a pilot study in which we combine behavioral testing in musical improvisation and structural neuroimaging to relate brain structure to performance in a creative musical improvisation task. Thirty-eight subjects completed a novel improvisation continuation task and underwent T1 MRI.

Constricted migration modulates stem cell differentiation.

Tissue regeneration at an injured site depends on proliferation, migration, and differentiation of resident stem or progenitor cells, but solid tissues are often sufficiently dense and constricting that nuclei are highly stressed by migration. In this study, constricted migration of myoblastic cell types and mesenchymal stem cells (MSCs) increases nuclear rupture, increases DNA damage, and modulates differentiation. Fewer myoblasts fuse into regenerating muscle in vivo after constricted migration in vitro, and myodifferentiation in vitro is likewise suppressed.

Methacrylate saccharide-based monomers for dental adhesive systems.

The aim of this study was to synthesize three new methacrylate monomers based on the modification of saccharides structures (glucose-Gluc, sucrose-Sucr and chitosan-Chit) with glycidyl methacrylate, and to use them in the composition of dental adhesives. Three methacrylate saccharide monomers were synthesized and characterized by mid-IR, H and C NMR, antioxidant activity and cytotoxic effect. Monomers included: one monosaccharide - Gluc-MA; one disaccharide - Sucr-MA; and one polysaccharide - Chit-MA.

MRA and ASL perfusion findings in pediatric reversible cerebral vasoconstriction syndrome.

Reversible vasoconstriction is rare in the pediatric population. Typically manifesting as peripheral vasoconstriction with variable neurologic symptoms, Reversible cerebral vasoconstriction syndrome is often a diagnosis of exclusion and may not be diagnosed in the absence of angiographic imaging. Shown here are 2 cases of pediatric Reversible cerebral vasoconstriction syndrome with disparate MRI findings and arterial spin labeling perfusion findings.

Opiate leukoencephalopathy in a pediatric patient.

A 17-year-old male presented from an outside facility in acute respiratory failure and profound hypotension. He was found to have classic MRI brain findings of opiate-induced leukoencephalopathy which was corroborated with urine drug screen and history. This entity has been described in the adults but is not as well recognized in the pediatric population.

Pontine tegmental cap dysplasia with a duplicated internal auditory canal.

Pontine tegmental cap dysplasia (PTCD) is a rare neurological syndrome that results in a hypoplastic ventral pons, tegmental cap at the dorsal pons, and cranial nerve dysfunction. The most common symptoms are hearing loss and speech problems. We present a case of a 9-month-old male who presented with developmental delay and hypotonia.

Underperforming light curing procedures trigger detrimental irradiance-dependent biofilm response on incrementally placed dental composites.

Objectives: Insufficient radiant exposure (J/cm) may provide an early trigger in a cascade of detrimental responses on incrementally-place composite, especially the bottom layer. This study aimed to assess the influence of poor radiant exposure, the degree of conversion (%DC), water sorption/ solubility and S. mutans biofilm formation on conventional, incrementally placed composites and to establish a relationship between these factors.

Fetal weight estimation at term - ultrasound versus clinical examination with Leopold's manoeuvres: a prospective blinded observational study.

Background: Fetal weight estimation is of key importance in the decision-making process for obstetric planning and management. The literature is inconsistent on the accuracy of measurements with either ultrasound or clinical examination, known as Leopold's manoeuvres, shortly before term. Maternal BMI is a confounding factor because it is associated with both the fetal weight and the accuracy of fetal weight estimation.

Bone Marrow Aspirate Concentrate for the Treatment of Avascular Meniscus Tears in a One-Step Procedure-Evaluation of an In Vivo Model.

Avascular meniscus tears show poor intrinsic regenerative potential. Thus, lesions within this area predispose the patient to developing knee osteoarthritis. Current research focuses on regenerative approaches using growth factors or mesenchymal stem cells (MSCs) to enhance healing capacity within the avascular meniscus zone.

TGF- Signalling is Suppressed under Pro-Hypertrophic Conditions in MSC Chondrogenesis Due to TGF- Receptor Downregulation.

Background And Objectives: Mesenchymal stem cells (MSCs) become hypertrophic in long term despite chondrogenic differentiation following the pathway of growth plate chondrocytes. This terminal differentiation leads to phenotypically unstable cartilage and was mirrored in vitro by addition of hypertrophy inducing medium. We investigated how intrinsic TGF- signaling is altered in pro-hypertrophic conditions.

Use of (meth)acrylamides as alternative monomers in dental adhesive systems.

Objectives: Methacrylamides are proposed as components for dental adhesive systems with enhanced resistance to hydrolytic and enzymatic degradation. The specific objective of this study was to evaluate the polymerization kinetics, water sorption and solubility, pH-derived degradation and microtensile bond strength of various monofunctional acrylamides and meth(acrylamides) when copolymerized with dimethacrylates.

Methods: Base monomers were added at 60 wt%, and included either BisGMA or UDMA.

Pediatric pyosalpinx without sexually transmitted infection: A report of 3 cases.

Pelvic inflammatory disease commonly occurs in adults and is most frequently caused by sexually-transmitted organisms. When left untreated, it can progress to abscess formation and subsequent infertility due to tubal scarring. This condition rarely occurs in the pediatric population and even less frequently in the absence of sexual activity.

Toughening of Dental Composites with Thiourethane-Modified Filler Interfaces.

Stress of polymerization is one of the most significant drawbacks of dental resin composites, since it is related to poor marginal adaptation, postoperative pain, and secondary caries. Previous studies have shown that thiourethane oligomers incorporated into the organic matrix represents a promising strategy to reduce stress and increase fracture toughness in dental composites. However, this strategy promotes a significant increase of the viscosity system, which may represent a challenge for clinical application.

The ATP-Binding Cassette Gene ABCF1 Functions as an E2 Ubiquitin-Conjugating Enzyme Controlling Macrophage Polarization to Dampen Lethal Septic Shock.

Sepsis is a bi-phasic inflammatory disease that threatens approximately 30 million lives and claims over 14 million annually, yet little is known regarding the molecular switches and pathways that regulate this disease. Here, we have described ABCF1, an ATP-Binding Cassette (ABC) family member protein, which possesses an E2 ubiquitin enzyme activity, through which it controls the Lipopolysaccharide (LPS)- Toll-like Receptor-4 (TLR4) mediated gram-negative insult by targeting key proteins for K63-polyubiquitination. Ubiquitination by ABCF1 shifts the inflammatory profile from an early phase MyD88-dependent to a late phase TRIF-dependent signaling pathway, thereby regulating TLR4 endocytosis and modulating macrophage polarization from M1 to M2 phase.

Early functional rehabilitation after patellar dislocation-What procedures are daily routine in orthopedic surgery?

Introduction: Patellar dislocation and rupture of the medial patellofemoral ligament (MPFL) are frequently seen in daily orthopedic practice. Besides initial non-surgical treatment, surgery and subsequent rehabilitation are crucial for restoring stability in the femoropatellar joint. This study investigated current rehabilitation strategies after patellar dislocation because knowledge on this topic has been severely limited so far.