Directional microwave ablation in spine: experimental assessment of computational modeling.

Background: Despite the theoretical advantages of treating metastatic bone disease with microwave ablation (MWA), there are few reports characterizing microwave absorption and bioheat transfer in bone. This report describes a computational modeling-based approach to simulate directional microwave ablation (dMWA) in spine, supported by and pilot experiments in porcine vertebral bodies.

Materials And Methods: A 3D computational model of microwave ablation within porcine vertebral bodies was developed.

Transmission Coefficient-Based Monitoring of Microwave Ablation: Development and Experimental Evaluation in Ex Vivo Tissue.

Objectives: To assess the feasibility of monitoring transient evolution of thermal ablation zones with a microwave transmission coefficient-based technique.

Methods: Microwave ablation was performed in ex vivo bovine liver with two 2.45 GHz directional antennas.

Shaping the future of microwave tumor ablation: a new direction in precision and control of device performance.

Microwave ablation (MWA) is becoming an increasingly important minimally invasive treatment option for localized tumors in many organ systems due to recent advancements in microwave technology that have conferred many advantages over other tumor ablation modalities. Despite these improvements in technology and development of applicators for site-specific tumor applications, the vast majority of commercially available MWA applicators are generally designed to create large-volume, symmetric, ellipsoid or spherically-shaped treatment zones and often lack the consistency, predictability, and spatial control needed to treat tumor targets near critical structures that are vulnerable to inadvertent thermal injury. The relatively new development and ongoing translation of directional microwave ablation (DMWA) technology, however, has the potential to confer an added level of control over the treatment zone shape relative to applicator position, and shows great promise to expand MWA's clinical applicability in treating tumors in challenging locations.

Directional Microwave Ablation: Experimental Evaluation of a 2.45-GHz Applicator in Ex Vivo and In Vivo Liver.

Purpose: To experimentally characterize a microwave (MW) ablation applicator designed to produce directional ablation zones.

Materials And Methods: Using a 14-gauge, 2.45-GHz side-firing MW ablation applicator, 36 ex vivo bovine liver ablations were performed.

Duration of hyperventilation and outcome in infants with persistent pulmonary hypertension.

Twenty-one infants with the diagnosis of persistent pulmonary hypertension had serial assessments of growth and neurologic development through 12 months of corrected age. Seven infants (30%) had one or more adverse physical outcomes during the first year of life. Four infants (19%) had severe neurologic impairment; seven babies had mild to moderate delay, and 11 babies were found to have no abnormality.